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Table of Contents
Preface; Contents; Abbreviations; Prologue: Lipidology
The Science of Lipids; Part IThe Overlooked Molecules; 1 Life from Molecules; 1.1 The Three Kingdoms of Life; 1.2 The Molecules of Life; 1.3 A Brief Historical Overview of Membrane Theory; 1.4 Membranes in Cellular Systems; 1.5 The Post-genomic Era; 1.6 A Call for Physics; 2 Head and Tail; 2.1 Fat Family: Fats and Fatty Acids; 2.2 The Polar Lipids
Both Head and Tail; 2.3 Cholesterol
A Lipid of Its Own; 2.4 Strange Lipids; 2.5 Lipid Composition of Membranes; 3 Oil and Water; 3.1 Water
The Biological Solvent.
3.2 The Hydrophobic Effect3.3 Mediating Oil and Water; 3.4 Self-assembly and the Lipid Aggregate Family; 3.5 Thermodynamics of Lipid Self-assembly; 3.6 Plucking Lipids; 4 Lipids Speak the Language of Curvature; 4.1 How Large Is a Lipid Molecule?; 4.2 Lipid Molecules Have Shape; 4.3 Lipid Structures with Curvature; 4.4 Microorganisms' Sense for Curvature; 5 A Matter of Softness; 5.1 Soft Matter; 5.2 Soft Interfaces ; 5.3 Forces Between Soft Interfaces; 5.4 Lipid Membranes are Really Soft; 6 Soft Shells Shape Up; 6.1 Bending Interfaces; 6.2 Spontaneous Curvature; 6.3 Shaping Membranes.
6.4 Red Blood Cells Shape Up7 Biological Membranes
Models and Fashion; 7.1 What Is a Model?; 7.2 Brief History of Membrane Models; 7.3 Do We Need a New Membrane Model?; 7.4 Theoretical and Experimental Model Systems; Part IILipids Make Sense; 8 Lipids in Bilayers
A Stress-Full and Busy Life; 8.1 Trans-Bilayer Structure; 8.2 The Lateral Pressure Profile; 8.3 How Thick are Membranes?; 8.4 Lively Lipids on the Move; 9 The More We Are Together; 9.1 Phase Transitions Between Order and Disorder; 9.2 Lipids Have Phase Transitions; 9.3 Mixing Different Lipids.
9.4 Cholesterol Brings Lipids to Order10 Lipids in Flatland; 10.1 Gases, Liquids, and Solids in Two Dimensions; 10.2 Langmuir and Langmuir-Blodgett Films; 10.3 Pattern Formation in Lipid Monolayers; 10.4 Lipids Make the Lung Work; 11 Social Lipids; 11.1 Lateral Membrane Structure; 11.2 Imaging Lipid Domains; 11.3 Lateral Membrane Heterogeneity and Domains; 11.4 Membrane Domains Carry Function; 11.5 Active Membranes; 12 Lively Lipids Provide for Function; 12.1 Leaky and Thirsty Membranes; 12.2 Repelling Membranes; 12.3 Enzymes Can Sense Membrane Transitions; 12.4 Lipid Thermometer in Lizards.
13 Proteins at Lipid Mattresses13.1 Coming to Terms with Lipids; 13.2 Anchoring at Membranes; 13.3 Spanning the Membrane; Part IIILipids in Action; 14 Cholesterol on the Scene; 14.1 Molecule of the Century; 14.2 Evolutionary Perfection of a Small Molecule; 14.3 Cholesterol Fit for Life; 14.4 Cholesterol as a Killer; 15 Lipids in Charge; 15.1 Lipids and Proteins Match Up; 15.2 Stressing Proteins to Function; 15.3 Lipids Opening Channels; 15.4 Lipids Mediate Fusion; 16 Being Smart
A Fishy Matter of Fat; 16.1 The Essential Fatty Acids; 16.2 Evolution of the Human Brain.
The Science of Lipids; Part IThe Overlooked Molecules; 1 Life from Molecules; 1.1 The Three Kingdoms of Life; 1.2 The Molecules of Life; 1.3 A Brief Historical Overview of Membrane Theory; 1.4 Membranes in Cellular Systems; 1.5 The Post-genomic Era; 1.6 A Call for Physics; 2 Head and Tail; 2.1 Fat Family: Fats and Fatty Acids; 2.2 The Polar Lipids
Both Head and Tail; 2.3 Cholesterol
A Lipid of Its Own; 2.4 Strange Lipids; 2.5 Lipid Composition of Membranes; 3 Oil and Water; 3.1 Water
The Biological Solvent.
3.2 The Hydrophobic Effect3.3 Mediating Oil and Water; 3.4 Self-assembly and the Lipid Aggregate Family; 3.5 Thermodynamics of Lipid Self-assembly; 3.6 Plucking Lipids; 4 Lipids Speak the Language of Curvature; 4.1 How Large Is a Lipid Molecule?; 4.2 Lipid Molecules Have Shape; 4.3 Lipid Structures with Curvature; 4.4 Microorganisms' Sense for Curvature; 5 A Matter of Softness; 5.1 Soft Matter; 5.2 Soft Interfaces ; 5.3 Forces Between Soft Interfaces; 5.4 Lipid Membranes are Really Soft; 6 Soft Shells Shape Up; 6.1 Bending Interfaces; 6.2 Spontaneous Curvature; 6.3 Shaping Membranes.
6.4 Red Blood Cells Shape Up7 Biological Membranes
Models and Fashion; 7.1 What Is a Model?; 7.2 Brief History of Membrane Models; 7.3 Do We Need a New Membrane Model?; 7.4 Theoretical and Experimental Model Systems; Part IILipids Make Sense; 8 Lipids in Bilayers
A Stress-Full and Busy Life; 8.1 Trans-Bilayer Structure; 8.2 The Lateral Pressure Profile; 8.3 How Thick are Membranes?; 8.4 Lively Lipids on the Move; 9 The More We Are Together; 9.1 Phase Transitions Between Order and Disorder; 9.2 Lipids Have Phase Transitions; 9.3 Mixing Different Lipids.
9.4 Cholesterol Brings Lipids to Order10 Lipids in Flatland; 10.1 Gases, Liquids, and Solids in Two Dimensions; 10.2 Langmuir and Langmuir-Blodgett Films; 10.3 Pattern Formation in Lipid Monolayers; 10.4 Lipids Make the Lung Work; 11 Social Lipids; 11.1 Lateral Membrane Structure; 11.2 Imaging Lipid Domains; 11.3 Lateral Membrane Heterogeneity and Domains; 11.4 Membrane Domains Carry Function; 11.5 Active Membranes; 12 Lively Lipids Provide for Function; 12.1 Leaky and Thirsty Membranes; 12.2 Repelling Membranes; 12.3 Enzymes Can Sense Membrane Transitions; 12.4 Lipid Thermometer in Lizards.
13 Proteins at Lipid Mattresses13.1 Coming to Terms with Lipids; 13.2 Anchoring at Membranes; 13.3 Spanning the Membrane; Part IIILipids in Action; 14 Cholesterol on the Scene; 14.1 Molecule of the Century; 14.2 Evolutionary Perfection of a Small Molecule; 14.3 Cholesterol Fit for Life; 14.4 Cholesterol as a Killer; 15 Lipids in Charge; 15.1 Lipids and Proteins Match Up; 15.2 Stressing Proteins to Function; 15.3 Lipids Opening Channels; 15.4 Lipids Mediate Fusion; 16 Being Smart
A Fishy Matter of Fat; 16.1 The Essential Fatty Acids; 16.2 Evolution of the Human Brain.