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Introduction.- Epidemiology, risk factors and survival in CUP: pointers to disease mechanisms
Biologic features of CUP
Prognostic factors and their role in the management of CUP
Diagnostic work-up of CUP
an approach to current recommendations and underlying evidence
The radiologist's approach to CUP
Cancer of unknown primary: the pathologist's approach
Treatment of disseminated CUP
Concepts of radiotherapy in cancer of unknown primary
Favorable subsets of CUP
Novel Diagnostic and Therapeutic Strategies in the Management of Patients with Cancers of Unknown Primary Site
Future directions.

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