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000752143 019__ $$a931592183$$a932333545
000752143 020__ $$a9783662486221$$q(electronic book)
000752143 020__ $$a3662486229$$q(electronic book)
000752143 020__ $$z9783662486207
000752143 0247_ $$a10.1007/978-3-662-48622-1$$2doi
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000752143 049__ $$aISEA
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000752143 08204 $$a615.6$$223
000752143 1001_ $$aChen, Yu,$$eauthor.
000752143 24510 $$aDesign, synthesis, multifunctionalization and biomedical applications of multifunctional mesoporous silica-based drug delivery nanosystems$$h[electronic resource] /$$cYu Chen.
000752143 264_1 $$aHeidelberg :$$bSpringer,$$c[2016]
000752143 300__ $$a1 online resource.
000752143 336__ $$atext$$btxt$$2rdacontent
000752143 337__ $$acomputer$$bc$$2rdamedia
000752143 338__ $$aonline resource$$bcr$$2rdacarrier
000752143 4901_ $$aSpringer theses
000752143 500__ $$aDoctoral Thesis accepted by Chinese Academy of Sciences, P.R. China.
000752143 504__ $$aIncludes bibliographical references.
000752143 5050_ $$aSupervisor's Foreword; Acknowledgments; Contents; 1 Research Background; 1.1 Introduction; 1.2 Synthetic Methodologies and Structures of Mesoporous Materials; 1.2.1 Formation Mechanism of Mesoporous Materials; 1.2.2 Structures of Mesoporous Materials; 1.3 Biomedical Applications of Mesoporous Materials; 1.3.1 Mesoporous Materials for Drug Loading and Sustained Release; 1.3.2 Mesoporous Materials for Controlled Drug Releasing; 1.3.3 Mesoporous Materials for Photodynamic Therapy; 1.3.4 Mesoporous Materials for Synergistic Therapy; 1.3.5 MSNs for Targeted Drug Delivery.
000752143 5058_ $$a1.3.6 Mesoporous Materials for Theranostic Applications1.3.6.1 Magnetic Resonance Imaging (MRI); 1.3.6.2 Fluorescent Imaging; 1.3.6.3 Multi-modality Diagnostic Imaging; 1.4 The Development Trends of Mesoporous Materials; 1.5 Significance of this Thesis; References; 2 Synthesis of Hollow Mesoporous Silica Nanoparticles by Silica-Etching Chemistry for Biomedical Applications; 2.1 Introduction; 2.2 Experimental Section; 2.2.1 Synthesis of HMSNs Based on SDSE Strategy; 2.2.2 Synthesis of HMSNs by Chemical Etching in Ammonia Solution; 2.2.3 Study of the Formation Mechanism of HMSNs.
000752143 5058_ $$a2.2.4 Synthesis of Multifunctional Rattle-Type HMSNs Based on SDSE Strategy2.2.5 Hemolytic Effect Evaluation; 2.2.6 In Vitro DOX-Loading into HMSNs; 2.2.7 MTT Evaluation of the Cytotoxicity of HMSNs and DOX-HMSNs; 2.3 Results and Discussion; 2.3.1 Synthesis and Characterization of HMSNs; 2.3.2 Synthesis of Multifunctional M@mSiO2 Nanorattles; 2.3.3 HMSNs for Anticancer Drug Delivery; 2.4 Conclusions; References; 3 Multifunctional Mesoporous Silica Nanoparticles for Theranostics of Cancer; 3.1 Introduction; 3.2 Experimental Section; 3.2.1 Synthesis of Fe3O4@mSiO2.
000752143 5058_ $$a3.2.2 Synthesis of Gd-Si-DPTA-Au@mSiO23.2.3 Blood Compatibility of Fe3O4@mSiO2; 3.2.4 In Vitro Cytotoxicity of Fe3O4@mSiO2 Nanocapsules; 3.2.5 Drug-Loading and Anticancer Efficiency; 3.2.6 CLSM Observations of the Cell Internalization of Fe3O4@mSiO2 Nanocapsules; 3.2.7 Bio-TEM Observations; 3.2.8 In Vitro and In Vivo MR Imaging; 3.2.9 Dark-Field Microscopic Labeling of HeLa Cancer Cells; 3.3 Results and Discussion; 3.3.1 Synthesis of Characterization of Fe3O4@mSiO2; 3.3.2 Magnetic Fe3O4@mSiO2 for MRI and Anticancer Drug Delivery.
000752143 5058_ $$a3.3.3 Synthesis of Gd-Si-DTPA-Grafted Au@mSiO2 for Biomedical Applications3.4 Conclusions; References; 4 Hollow Mesoporous Silica Nanoparticles for Ultrasound-Based Cancer Diagnosis and Therapy; 4.1 Introduction; 4.2 Experimental Section; 4.2.1 Material Synthesis; 4.2.2 In Vitro MRI Evaluation; 4.2.3 Ex Vivo Evaluation Toward the HIFU Synergistic Effect of IMNCs, PFH-IMNCs, MCNCs, and PFH-MCNCs; 4.2.4 CLSM Observation of Intracellular Uptake and Location of RITC-MCNCs.
000752143 506__ $$aAccess limited to authorized users.
000752143 520__ $$aThis thesis reports on essential advances in the design, synthesis and biomedical applications of multifunctional Mesoporous Silica Nanoparticles (MSNs). It provides several examples of multifunctional MSN-based drug delivery nanosystems and demonstrates successful synergistic cancer therapies combining MSNs and high-intensity focused ultrasound. The book will especially be of interest to researchers and graduate students in the fields of biomaterials, biology, chemistry, medicine and the life sciences who are working to develop new methods and technologies to combat cancer.
000752143 588__ $$aOnline resource; title from PDF title page (viewed October 27, 2015).
000752143 650_0 $$aDrug delivery systems.
000752143 650_0 $$aNanoparticles.
000752143 650_0 $$aMesoporous materials.
000752143 77608 $$iPrint version:$$aChen, Yu.$$tDesign, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems.$$dBerlin, Heidelberg : Springer Berlin Heidelberg, ©2015$$z9783662486207
000752143 830_0 $$aSpringer theses.
000752143 852__ $$bebk
000752143 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-662-48622-1$$zOnline Access$$91397441.1
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000752143 980__ $$aEBOOK
000752143 980__ $$aBIB
000752143 982__ $$aEbook
000752143 983__ $$aOnline
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