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Table of Contents
Preface; Acknowledgments; Contents; Contributors; Part I: Ovary, Fallopian Tube and Peritoneum; 1: Precursors of High-Grade Serous Carcinoma; Introduction; Historical Perspective; Classification of Serous Carcinoma; HGSC Cell of Origin; BRCA and HGSC; High-Grade Serous Carcinoma, Occult; Macroscopic; Microscopic; Outcome; Molecular Pathology; Serous Tubal Intraepithelial Carcinoma; Microscopic; Molecular Pathology; Outcome; Controversy; P53 Signature; Microscopic; Molecular Pathology; Serous Tubal Intraepithelial Lesion; Microscopic; Controversy; Secretory Cell Outgrowths.
Processing of Salpingectomy Specimens Summary; References; 2: Precursors of Low-Grade Serous Adenocarcinoma of the Ovary: Pathology and Molecular Pathways; Introduction; Histology; Typical SBT; Micropapillary SBT; SBT with Microinvasion; Peritoneal Implants; Ovarian Grading Systems and Low-Grade Ovarian Serous Carcinoma; Cellular Origins; Ovarian Epithelial Cells; Fallopian Epithelial Cells; Endometriosis Epithelial Cells; The Microenvironment of the Ovary; Somatic Genetic Characteristics of LGSC; Conclusion; References.
3: Precancerous Lesions of Ovarian Clear Cell and Endometrioid CarcinomasEndometriosis; History of Endometriosis; Origin of Endometriosis; Metaplastic Changes and Atypical Morphologic Features of Endometriosis; Molecular Features of Ovarian Endometriosis and Associated Carcinomas; Clear Cell Adenofibroma; Features of Clear Cell Adenofibroma; Evidence for Clear Cell Adenofibroma as Precursor Lesion of Clear Cell Carcinoma; Endometrioid Adenofibroma; Features of Endometrioid Adenofibroma; Evidence for Endometrioid Adenofibroma as Precursor Lesion of Endometrioid Carcinoma.
Fallopian Tube Origin of Ovarian Endometrioid Carcinomas? Summary; References; 4: Clinical Management of Selected Precancerous Lesions of the Uterus, Fallopian Tube, and Ovary; Introduction; Precancerous Lesions of the Uterus; Endometrial Hyperplasia; Serous Endometrial Intraepithelial Carcinoma; Serous Tubal Intraepithelial Carcinoma; Ovarian Atypical Endometriosis; Miscellaneous Ovarian Precursors; References; Part II: Uterine Corpus; 5: Putative Precursor Lesions of Gestational Trophoblastic Neoplasia; Introduction; Hydatidiform Moles; Genetic Basis of Molar Gestations.
Clinical Presentation Gross and Microscopic Features; Complete Hydatidiform Mole; Partial Hydatidiform Mole; Ancillary Studies; Ploidy Analysis; P57 Immunohistochemistry; Short Tandem Repeat Genotyping; Differential Diagnosis; Proposed Diagnostic Algorithm of Hydatidiform Moles; Invasive and Metastatic Hydatidiform Mole; In Situ or Intraplacental Choriocarcinoma; Atypical Placental Site Nodule; Atypical Exaggerated Placental Site; References; 6: Putative Precursors of Uterine Sarcomas; Introduction; Uterine Carcinosarcoma; Clinical Features; Pathological Features.
Processing of Salpingectomy Specimens Summary; References; 2: Precursors of Low-Grade Serous Adenocarcinoma of the Ovary: Pathology and Molecular Pathways; Introduction; Histology; Typical SBT; Micropapillary SBT; SBT with Microinvasion; Peritoneal Implants; Ovarian Grading Systems and Low-Grade Ovarian Serous Carcinoma; Cellular Origins; Ovarian Epithelial Cells; Fallopian Epithelial Cells; Endometriosis Epithelial Cells; The Microenvironment of the Ovary; Somatic Genetic Characteristics of LGSC; Conclusion; References.
3: Precancerous Lesions of Ovarian Clear Cell and Endometrioid CarcinomasEndometriosis; History of Endometriosis; Origin of Endometriosis; Metaplastic Changes and Atypical Morphologic Features of Endometriosis; Molecular Features of Ovarian Endometriosis and Associated Carcinomas; Clear Cell Adenofibroma; Features of Clear Cell Adenofibroma; Evidence for Clear Cell Adenofibroma as Precursor Lesion of Clear Cell Carcinoma; Endometrioid Adenofibroma; Features of Endometrioid Adenofibroma; Evidence for Endometrioid Adenofibroma as Precursor Lesion of Endometrioid Carcinoma.
Fallopian Tube Origin of Ovarian Endometrioid Carcinomas? Summary; References; 4: Clinical Management of Selected Precancerous Lesions of the Uterus, Fallopian Tube, and Ovary; Introduction; Precancerous Lesions of the Uterus; Endometrial Hyperplasia; Serous Endometrial Intraepithelial Carcinoma; Serous Tubal Intraepithelial Carcinoma; Ovarian Atypical Endometriosis; Miscellaneous Ovarian Precursors; References; Part II: Uterine Corpus; 5: Putative Precursor Lesions of Gestational Trophoblastic Neoplasia; Introduction; Hydatidiform Moles; Genetic Basis of Molar Gestations.
Clinical Presentation Gross and Microscopic Features; Complete Hydatidiform Mole; Partial Hydatidiform Mole; Ancillary Studies; Ploidy Analysis; P57 Immunohistochemistry; Short Tandem Repeat Genotyping; Differential Diagnosis; Proposed Diagnostic Algorithm of Hydatidiform Moles; Invasive and Metastatic Hydatidiform Mole; In Situ or Intraplacental Choriocarcinoma; Atypical Placental Site Nodule; Atypical Exaggerated Placental Site; References; 6: Putative Precursors of Uterine Sarcomas; Introduction; Uterine Carcinosarcoma; Clinical Features; Pathological Features.