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Introduction
Background to the hunt for the human chromosome number
Microscopes and stains: the rise of technology
Mendel and genetics
Chromosomes as the carriers of heredity
Difficulties of chromosome handling and access to material
The implications of DNA structure
Tissue culture and the cell cycle: the answer is revealed
The flowering of clinical genetics
Sex and chromosomes
What we know, what we dont́ and where this may lead us.

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