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000753110 019__ $$a933442873
000753110 020__ $$a9783319237930$$q(electronic book)
000753110 020__ $$a3319237934$$q(electronic book)
000753110 020__ $$z9783319237923
000753110 0247_ $$a10.1007/978-3-319-23793-0$$2doi
000753110 035__ $$aSP(OCoLC)ocn933509597
000753110 035__ $$aSP(OCoLC)933509597$$z(OCoLC)933442873
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000753110 049__ $$aISEA
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000753110 24500 $$aOrganic cation transporters$$h[electronic resource] :$$bintegration of physiology, pathology, and pharmacology /$$cGiuliano Ciarimboli, Sophie Gautron, Eberhard Schlatter, editors.
000753110 264_1 $$aCham :$$bSpringer,$$c[2015]
000753110 264_4 $$c©2016
000753110 300__ $$a1 online resource (xv, 264 pages) :$$billustrations.
000753110 336__ $$atext$$btxt$$2rdacontent
000753110 337__ $$acomputer$$bc$$2rdamedia
000753110 338__ $$aonline resource$$bcr$$2rdacarrier
000753110 500__ $$aIncludes index.
000753110 5050_ $$aIntroduction to the cellular transport of organic cations -- Functional properties of organic cation transporter OCT1, binding of substrates and inhibitors, and presumed transport mechanism -- Pharmacological and toxicological significance of the organic cation transporters OCT and MATE: Drug disposition, interaction and toxicity -- Genetic variability in organic cation transporters: pathophysiological manifestations and consequences for drug pharmacokinetics and efficacy -- Physiological and pathological regulation of transporters for organic cations -- Endocrine and metabolic regulation of transporters for organic cations -- Organic cation transporters (OCTs) as modulators of behavior and mood -- Organic cation transporters as modulators of neurodegeneration and neuroprotection -- Translational relevance of animal models for the study of organic cation transporter function -- Role of transporters for organic cations in plants for environmental cycling of pharmaceutical residues.
000753110 506__ $$aAccess limited to authorized users.
000753110 520__ $$aThis innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.
000753110 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed December 28, 2015).
000753110 650_0 $$aCarrier proteins.
000753110 650_0 $$aCations.
000753110 7001_ $$aCiarimboli, Giuliano,$$d1962-$$eeditor.
000753110 7001_ $$aGautron, Sophie,$$eeditor.
000753110 7001_ $$aSchlatter, Eberhard,$$eeditor.
000753110 77608 $$iPrint version:$$z9783319237923
000753110 852__ $$bebk
000753110 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-23793-0$$zOnline Access$$91397441.1
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000753110 982__ $$aEbook
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