B cell receptor signaling [electronic resource] / Tomohiro Kurosaki, Jürgen Wienands, editors.

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B cell receptor signaling [electronic resource] / Tomohiro Kurosaki, Jürgen Wienands, editors.

9783319261331 (electronic book)
3319261339 (electronic book)
9783319261317
3319261312

Cham : Springer, ©2016.

English

1 online resource.

10.1007/978-3-319-26133-1 doi

QR185.8.B15

571.9/67
610

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton?s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

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Description based on print version record.

Current topics in microbiology and immunology ; v. 393.

Print version: 9783319261317

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