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Foreword; Contents; Part I: Current Heart Failure Therapies; 1: Introduction; References; 2: Therapies in Heart Failure, Tomorrow May Be Too Late; 2.1 The Heart Failure Pandemic and the "Halfway Technology" Swamp; 2.2 Current Heart Failure Therapy: The Achievements of Yesterday, the Hurdles of Today; 2.3 Heart Failure Therapy Tomorrow: Looking outside (Beyond) the Current Therapeutic Window; References; 3: Atrial Fibrillation, Heart Failure, and the Autonomic Nervous System; 3.1 Treatment of Atrial Fibrillation in the Heart Failure Population; 3.2 Autonomic Nervous System and AF
3.3 Ganglionic Plexi: Autonomic Modulation in the Treatment of Atrial Fibrillation3.4 Renal Denervation; 3.5 Alternative Therapies for Neuromodulation; Conclusions; References; 4: Current Therapies for Ventricular Tachycardia: Are there Autonomic Implications of the Arrhythmogenic Substrate?; References; Part II: The Autonomic Regulation and Dis- regulation of the Heart: Pathophysiology in Heart Failure; 5: "The Autonomic Nervous System Symphony Orchestra": Pathophysiology of Autonomic Nervous System and Analysis of Activity Frequencies; 5.1 Introduction; 5.2 Methodologies
5.2.1 General Considerations5.2.2 Muscle Sympathetic Nerve Activity (MSNA); 5.2.3 Heart Rate Variability; 5.2.3.1 Linear Analysis; 5.2.3.2 Nonlinear Analysis; 5.2.3.3 Symbolic Analysis; References; 6: Autonomic Pathophysiology After Myocardial Infarction Falling into Heart Failure; 6.1 Introduction; 6.2 The History; 6.3 Physiopathology of the Sympathetic Activation; 6.4 Nerve Sprouting After Myocardial Injury; 6.5 NGF Changes following an Ischemic Injury: From Short-Term to Long-Term Events; 6.6 From Acute Myocardial Injury to Chronic Heart Failure through Cardiac Remodeling
6.7 Molecular Pathophysiology of Cardiac Sympathetic Innervation Conclusions; References; 7: Cardiovascular Serenade: Listening to the Heart; 7.1 Introduction; 7.2 Heart Rate Variability; 7.3 Intrathoracic Impedance Measurement; 7.4 Implantable Hemodynamic Monitoring; 7.5 CHAMPION Trial; 7.6 CHAMPION Trial Results: Benefits of Listening to Central Hemodynamic Data; Conclusions; References; 8: Whispering During Sleep: Autonomic Signaling During Sleep, Sleep Apnea, and Sudden Death; 8.1 The Cardiovascular System and Sleep Architecture
9: Cerebral Aging: Implications for the Heart Autonomic Nervous System Regulation9.1 Central Control of Sympathetic Outflow; 9.2 Gangliar Level Control; 9.3 Nerve Ending Level: Presynaptic Control and Postsynaptic Signaling; 9.3.1 Presynaptic Control; 9.3.2 Postsynaptic Signaling; 9.4 The Baroreceptor Reflex; 9.5 Plasticity of the Autonomic Nervous System, the Role of Neurotrophins; References; Part III: Modulation of Autonomic Function in Heart Failure; 10: The Autonomic Cardiorenal Crosstalk: Pathophysiology and Implications for Heart Failure Management; 10.1 Introduction
3.3 Ganglionic Plexi: Autonomic Modulation in the Treatment of Atrial Fibrillation3.4 Renal Denervation; 3.5 Alternative Therapies for Neuromodulation; Conclusions; References; 4: Current Therapies for Ventricular Tachycardia: Are there Autonomic Implications of the Arrhythmogenic Substrate?; References; Part II: The Autonomic Regulation and Dis- regulation of the Heart: Pathophysiology in Heart Failure; 5: "The Autonomic Nervous System Symphony Orchestra": Pathophysiology of Autonomic Nervous System and Analysis of Activity Frequencies; 5.1 Introduction; 5.2 Methodologies
5.2.1 General Considerations5.2.2 Muscle Sympathetic Nerve Activity (MSNA); 5.2.3 Heart Rate Variability; 5.2.3.1 Linear Analysis; 5.2.3.2 Nonlinear Analysis; 5.2.3.3 Symbolic Analysis; References; 6: Autonomic Pathophysiology After Myocardial Infarction Falling into Heart Failure; 6.1 Introduction; 6.2 The History; 6.3 Physiopathology of the Sympathetic Activation; 6.4 Nerve Sprouting After Myocardial Injury; 6.5 NGF Changes following an Ischemic Injury: From Short-Term to Long-Term Events; 6.6 From Acute Myocardial Injury to Chronic Heart Failure through Cardiac Remodeling
6.7 Molecular Pathophysiology of Cardiac Sympathetic Innervation Conclusions; References; 7: Cardiovascular Serenade: Listening to the Heart; 7.1 Introduction; 7.2 Heart Rate Variability; 7.3 Intrathoracic Impedance Measurement; 7.4 Implantable Hemodynamic Monitoring; 7.5 CHAMPION Trial; 7.6 CHAMPION Trial Results: Benefits of Listening to Central Hemodynamic Data; Conclusions; References; 8: Whispering During Sleep: Autonomic Signaling During Sleep, Sleep Apnea, and Sudden Death; 8.1 The Cardiovascular System and Sleep Architecture
9: Cerebral Aging: Implications for the Heart Autonomic Nervous System Regulation9.1 Central Control of Sympathetic Outflow; 9.2 Gangliar Level Control; 9.3 Nerve Ending Level: Presynaptic Control and Postsynaptic Signaling; 9.3.1 Presynaptic Control; 9.3.2 Postsynaptic Signaling; 9.4 The Baroreceptor Reflex; 9.5 Plasticity of the Autonomic Nervous System, the Role of Neurotrophins; References; Part III: Modulation of Autonomic Function in Heart Failure; 10: The Autonomic Cardiorenal Crosstalk: Pathophysiology and Implications for Heart Failure Management; 10.1 Introduction