Preface; Contents; 1 Membrane Transport in Yeast, An Introduction; 1.1 Importance of Membrane Transport Processes; 1.2 Why Yeast?; 1.3 A Bit of "History"; 1.4 Mechanistic Processes Involved in Membrane Transport; 1.5 A Comment on Intracellular Membranes; 1.6 Are There Still New Interesting Discoveries in Yeast?; 1.7 Basic Versus Applied Research in Membrane Transport; 1.8 Overview of the Contributions; References; 2 Cell Surface Interference with Plasma Membrane and Transport Processes in Yeasts; 2.1 Introduction; 2.2 An Overview of the Structure and Biophysical Properties of Yeast Cell Wall

2.3 Cell Wall Porosity and Impact for Material Exchange2.4 Biosorbant and Selective Molecular Sieve Properties of the Yeast Cell Wall; 2.5 Inference of Cell Wall in Metal Ions Uptake and Ionome Homeostasis; 2.6 Inference of Cell Wall with Membrane Fluidity and Transport Processes from Genome Scale Analyses; 2.7 Summing Up; References; 3 Proton Transport and pH Control in Fungi; 3.1 Introduction; 3.2 The Physiological Context of pH Homeostasis in S. cerevisiae; 3.3 The Plasma Membrane H+-pump Pma1 and Organellar V-ATPases: Central Players in Cellular pH Control

3.3.1 Pma1 Structure, Function, and Genetics3.3.2 V-ATPases: Structure, Function, and Genetics; 3.3.3 Regulation of Pma1; 3.3.4 Regulation of V-ATPases; 3.3.5 Coordination of V-ATPase and Pma1 Activity; 3.3.6 Other Regulators of Cellular pH in Yeast; 3.4 Genomic Perspectives on H+-Transport and pH Control; 3.4.1 pH Measurements Across Deletion Mutant Arrays; 3.4.2 A Systems-Level View of Cytosolic pH Control; 3.4.3 A Systems-Level View of Vacuolar pH Control; 3.4.4 Cellular Responses to pH Stress; 3.5 pH as a Growth Signal in S. cerevisiae; 3.6 Proton Transport and pH Control in Other Fungi

3.6.1 V-ATPase and Pma1 in Neurospora crassa3.6.2 pH Control in Pathogenic Fungi; 3.7 Conclusions and Future Directions; References; 4 Function and Regulation of Fungal Amino Acid Transporters: Insights from Predicted Structure; 4.1 Introduction; 4.2 Classification of Fungal Amino Acid Transporters; 4.3 Structure-Function Relationships and Determination of Specificity in the YAT Family; 4.3.1 The YAT-Family Proteins Adopt the LeuT Fold; 4.3.2 Using Structural Models to Study Substrate Binding and Translocation in YATs; 4.3.2.1 Residues Mediating Recognition of the Amino-Acid Backbone

4.3.2.2 Residues in Several TMs Mediate Recognition of Amino Acid Side Chains4.3.2.3 Role of Proximal and Middle Gate Residues; 4.3.2.4 Role of Distal Gate Residues; 4.3.3 Genetically Isolated Specificity-Affecting YAT Mutants Altered in TM Domains; 4.3.4 Role of Intracellular and Extracellular Loops in Substrate Selectivity; 4.3.5 Summary; 4.4 Substrate-Mediated Endocytosis; 4.4.1 Inhibition of Transporters by Selective Endocytosis: General Principles; 4.4.2 Substrate-Induced Endocytosis of Fungal Amino Acid Transporters