The Th2 type immune response in health and disease [electronic resource] : from host defense and allergy to metabolic homeostasis and beyond / William C. Gause, David Artis, Editors.
Gause, William C., editor.; Artis, David, editor.
2016
QR185.8.T24 T48 2016
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Title
The Th2 type immune response in health and disease [electronic resource] : from host defense and allergy to metabolic homeostasis and beyond / William C. Gause, David Artis, Editors.
ISBN
9781493929115 (electronic book)
1493929119 (electronic book)
9781493929108
1493929100
DOI
https://doi.org/10.1007/978-1-4939-2911-5
Published
New York : Springer, [2016]
Language
English
Description
1 online resource (xiv, 172 pages) : illustrations.
Item Number
10.1007/978-1-4939-2911-5 doi
Call Number
QR185.8.T24 T48 2016
Dewey Decimal Classification
616.079
Summary
The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice. This response is complex and includes effector functions that mediate resistance, contributing to expulsion, and in some cases destruction, of the parasite. But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs. The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis. In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Source of Description
Description based on print version record.
Added Author
Gause, William C., editor.
Artis, David, editor.
Available in Other Form
Print version: 1493929100
Th2 Type Immune Response in Health and Disease.
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Record Appears in
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All Resources
Regulation and Function of Basophil, Eosinophil and Mast Cell Responses
Innate lymphoid cells: An Emerging Population in type 2 Inflammation
Dendritic Cells and Type 2 Inflammation
Th2 Cell Responses in Immunity and Inflammation Following Helminth Infection
Regulatory T Cell Control of Type 2 Inflammation
Developments in the Design of Anti-Helminth Vaccines
Tissue Remodeling and Repair During Type 2 Inflammation
Immune Response to Helminth Infections and as Treatment for Autoimmune Disorders
Type 2 Immunity and Metabolism.

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