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000753476 019__ $$a936146518$$a936202266$$a937403900
000753476 020__ $$a9783319289014$$q(electronic book)
000753476 020__ $$a3319289012$$q(electronic book)
000753476 020__ $$z9783319289007
000753476 020__ $$z3319289004
000753476 0247_ $$a10.1007/978-3-319-28901-4$$2doi
000753476 035__ $$aSP(OCoLC)ocn936040200
000753476 035__ $$aSP(OCoLC)936040200$$z(OCoLC)936146518$$z(OCoLC)936202266$$z(OCoLC)937403900
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000753476 049__ $$aISEA
000753476 050_4 $$aRS199.5
000753476 08204 $$a615/.6$$223
000753476 1001_ $$aGarvie-Cook, Hazel,$$eauthor.
000753476 24510 $$aNovel (trans)dermal drug delivery strategies$$h[electronic resource] :$$bmicro- and nano-scale assessments /$$cHazel Garvie-Cook.
000753476 264_1 $$aSwitzerland :$$bSpringer,$$c[2016]
000753476 300__ $$a1 online resource.
000753476 336__ $$atext$$btxt$$2rdacontent
000753476 337__ $$acomputer$$bc$$2rdamedia
000753476 338__ $$aonline resource$$bcr$$2rdacarrier
000753476 4901_ $$aSpringer theses
000753476 500__ $$aDoctoral thesis accepted by the University of Bath, UK.
000753476 504__ $$aIncludes bibliographical references.
000753476 5050_ $$aIntroduction -- Background -- Methodology -- TEC Plasticization of Topical Polymeric Films -- Lipid Incorporation into Topical Polymeric Films -- Laser Microporation of Skin -- Conclusion.
000753476 506__ $$aAccess limited to authorized users.
000753476 520__ $$aThis work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.
000753476 650_0 $$aDrug delivery systems.
000753476 650_0 $$aDrug delivery systems$$xTechnological innovations.
000753476 650_0 $$aTransdermal medication.
000753476 650_0 $$aBioelectronics.
000753476 77608 $$iPrint version:$$z9783319289007
000753476 830_0 $$aSpringer theses.
000753476 852__ $$bebk
000753476 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-28901-4$$zOnline Access$$91397441.1
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000753476 980__ $$aEBOOK
000753476 980__ $$aBIB
000753476 982__ $$aEbook
000753476 983__ $$aOnline
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