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000753482 020__ $$a9784431558736$$q(electronic book)
000753482 020__ $$a443155873X$$q(electronic book)
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000753482 0247_ $$a10.1007/978-4-431-55873-6$$2doi
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000753482 035__ $$aSP(OCoLC)936040267
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000753482 08204 $$a572.8/645$$223
000753482 24500 $$aDNA replication, recombination, and repair$$h[electronic resource] :$$bmolecular mechanisms and pathology /$$cFumio Hanaoka, Kaoru Sugasawa, editors.
000753482 264_1 $$aTokyo :$$bSpringer,$$c2016.
000753482 300__ $$a1 online resource (ix, 555 pages) :$$billustrations.
000753482 336__ $$atext$$btxt$$2rdacontent
000753482 337__ $$acomputer$$bc$$2rdamedia
000753482 338__ $$aonline resource$$bcr$$2rdacarrier
000753482 500__ $$aIncludes index.
000753482 5050_ $$aPart 1 DNA Replication -- 1 Molecular Mechanism of DNA Replication -- 2 Characteristics of Metazoan DNA Replication Origins -- 3 DNA Replication Timing: Temporal and Spatial Regulation of Eukaryotic DNA Replication -- Part 2 DNA Recombination -- 4 Mechanism of Homologous Recombination -- 5 Regulation of Recombination by Chromatin -- 6 Homologous Recombination During Meiosis -- Part 3 DNA Repair -- 7 DNA Damage Recognition and Repair in Mammalian Global Genome Nucleotide Excision Repair -- 8 The Fanconi Anemia Pathway and Interstrand Crosslink Repair -- 9 The Crossroads of Ubiquitination and DNA Repair: A Structural Perspective -- Part 4 Genome Instability and Mutagenesis -- 10 Genome Instability of Repetitive Sequence: Lesson From the Ribosomal RNA Gene Repeat -- 11 Translesion DNA Synthesis and Damage Tolerance Pathways -- 12 Mismatch Repair -- 13 Non-Homologous End-Joining -- Part 5 Chromosome Dynamics and Functions -- 14 Centromeric Chromatin and Kinetochore Assembly in Vertebrate Cells -- 15 CST Complex and Telomere Maintenance -- Part 6 Cell Cycle and Checkpoints -- 16 Signaling of DNA Replication Stress Through the ATR Checkpoint -- 17 Spindle Assembly Checkpoint: Its Control and Aberration -- 18 Molecular Insights Into the Regulation of Apoptosis and Cellular Senescence and Their Implications for Cancer -- Part 7 Interplay with Transcription and Epigenetic Regulation -- 19 DNA Replication and Histone M odification -- 20 Establishment and Maintenance of DNA Methylation -- 21 Active DNA Demethylation in Development, Human Disease, and Cancer -- BM Index.
000753482 506__ $$aAccess limited to authorized users.
000753482 520__ $$aThis book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1-3), DNA Replication; Part 2 (Chapters 4-6), DNA Recombination; Part 3 (Chapters 7-9), DNA Repair; Part 4 (Chapters 10-13), Genome Instability and Mutagenesis; Part 5 (Chapters 14-15), Chromosome Dynamics and Functions; Part 6 (Chapters 16-18), Cell Cycle and Checkpoints; Part 7 (Chapters 19-21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.
000753482 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed January 27, 2016).
000753482 650_0 $$aDNA replication.
000753482 650_0 $$aDNA repair.
000753482 650_0 $$aGene rearrangement.
000753482 7001_ $$aHanaoka, Fumio,$$d1946-$$eeditor.
000753482 7001_ $$aSugasawa, Kaoru,$$eeditor.
000753482 77608 $$iPrint version:$$z9784431558712
000753482 852__ $$bebk
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000753482 980__ $$aBIB
000753482 982__ $$aEbook
000753482 983__ $$aOnline
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