Measuring biological impacts of nanomaterials [electronic resource] / Joachim Wegener, editor ; with contributions by C. Bantz [and more].
Wegener, Joachim, editor.
2016
TA418.9.N35
Available Online

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Title Measuring biological impacts of nanomaterials [electronic resource] / Joachim Wegener, editor ; with contributions by C. Bantz [and more].
ISBN 9783319248233 (electronic book)
3319248235 (electronic book)
9783319248219
DOI https://doi.org/10.1007/978-3-319-24823-3
Published Cham : Springer, 2016.
Language English
Description 1 online resource (ix, 214 pages) : illustrations.
Item Number 10.1007/978-3-319-24823-3 doi
Call Number TA418.9.N35
Dewey Decimal Classification 620.1/15
Summary This book reviews several aspects of the biological response to nanoscale particles on a molecular and cellular level. Nanoscale materials and nanoscale particles in particular have interesting properties and beneficial applications. While they thus have entered our daily lifes on many different levels (from electronics, over textiles, packaging or surface modifications, to biomedical applications), general rules describing their interaction with biological structures and biological matter are still difficult to derive. The existing literature suggests a variety of interaction schemes between nanoparticles and biological objects, not dispelling the public concerns about possible health effects and harmful properties. A systematic approach to the problem is needed and timely. This book specifically emphasizes bioanalytical problems starting from the characterization of the nanomaterials to the pitfalls and potential artifacts of state-of-the-art cytotoxicity assays that are frequently used to study harmful effects on cells. It also highlights the application of label-free bioanalytical techniques that can potentially complement the present approaches and hence provide new perspectives on this highly discussed cutting-edge field of research and public concern.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed February 8, 2016).
Added Author Wegener, Joachim, editor.
Series Bioanalytical reviews (Springer (Firm)) ; 5.
Available in Other Form Measuring Biological Impacts of Nanomaterials
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Preface; Contents; Characterization of Nanoparticles Under Physiological Conditions; 1 Nanoparticles: Definition; 2 Nanoparticles: Stability and Interactions; 3 Nanoparticles Under Physiological Conditions; 3.1 Relevant Media; 3.2 Effect of Physiological Salt Concentrations on Colloidal Properties; 3.3 The Nanomaterial Protein Corona; 4 Characterization Methods; 4.1 Scattering and Correlation Methods; 4.1.1 Light Scattering; 4.1.2 Zeta Potential Measurements; 4.1.3 X-Ray and Neutron Scattering; 4.1.4 Fluorescence Correlation Spectroscopy; 4.1.5 Particle Tracking Velocimetry

4.2 Microscopy-Based Methods4.2.1 Electron Microscopy; 4.2.2 Atomic Force Microscopy; 4.3 Analytical Methods Based on Hydrodynamic Separation; 4.3.1 Field-Flow Fractionation; 4.3.2 Flow Field-Flow Fractionation; 4.3.3 AF-FFF of Biomolecules; 4.3.4 Size Exclusion Chromatography; 4.3.5 Gel Electrophoresis; 4.3.6 Analytical Ultracentrifugation; 4.4 Comparison of Characterization Methods; References; Probing the Cytotoxicity of Nanoparticles: Experimental Pitfalls and Artifacts; 1 Introduction; 2 Validity of Cell Viability Assays; 3 Effects of Nanoparticle Labeling Processes on Cells

4 ConclusionReferences; Monitoring the Impact of Nanomaterials on Animal Cells by Impedance Analysis: A Noninvasive, Label-Free, and Multimodal Approa...; 1 Cell-Based Assays in Bioanalysis: Relevance, Requirements, and Restrictions; 2 Cells as Sensors; 3 Label-Free Versus Label-Based Assay Strategies; 3.1 Label-Based Analysis of Cell-Based Assays; 3.2 Label-Free Analysis of Cell-Based Assays; 3.3 Comparison of the Different Assay Strategies; 4 Basics and Concepts of Electric Cell-Substrate Impedance Sensing (ECIS); 4.1 Basic Concept of the Measurement

4.2 Impedance-Based Cell Monitoring: A Multimodal Platform Technology with Broad Applicability4.2.1 Kinetics of Cell Spreading; 4.2.2 Cell Proliferation; 4.2.3 Cytotoxicity (Apoptosis, Necrosis); 4.2.4 Cell Motility (Micromotion); 4.2.5 Time-Resolved Response Profiles; 4.2.6 Monitoring Epithelial and Endothelial Barrier Function; 4.2.7 Cell Migration/Wound Healing; 4.2.8 In Situ Electroporation; 4.3 Modeling the Impedance of Cell-Covered Electrodes; 5 Measuring the Biological Impact of Nanomaterials by Impedance Analysis: A Multimodal Approach; 5.1 Nanoparticle Impact on Cell Adhesion

5.2 Nanoparticle Impact on Cell Proliferation5.3 Time-Resolved Response Profiles: Cytotoxicity; 5.4 Nanoparticle Impact on Cell Migration; 5.5 Nanoparticle Impact on Cell Motility (Micromotion); 6 Conclusion and Outlook; References; Interaction of Nanoparticles with Lipid Monolayers and Lung Surfactant Films; 1 Introduction; 2 Interaction of Hydrophobic Nanoparticles with Lipid Monolayers; 3 The Pulmonary Surfactant Film at the Air-Alveolar Interface; 4 Deposition of Nanomaterials Along the Pulmonary Route and Their Interaction with the Pulmonary Surfactant Film

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