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000753722 020__ $$a9784431557081$$q(electronic book)
000753722 020__ $$a4431557083$$q(electronic book)
000753722 020__ $$z9784431557074
000753722 0247_ $$a10.1007/978-4-431-55708-1$$2doi
000753722 035__ $$aSP(OCoLC)ocn937392417
000753722 035__ $$aSP(OCoLC)937392417
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000753722 049__ $$aISEA
000753722 050_4 $$aRC924.5.S34
000753722 08204 $$a616.77$$223
000753722 24500 $$aSystemic sclerosis$$h[electronic resource] :$$bbasic and translational research /$$cKazuhiko Takehara, Manabu Fujimoto, Masataka Kuwana, editors.
000753722 264_1 $$aTokyo :$$bSpringer,$$c2016.
000753722 300__ $$a1 online resource
000753722 336__ $$atext$$btxt$$2rdacontent
000753722 337__ $$acomputer$$bc$$2rdamedia
000753722 338__ $$aonline resource$$bcr$$2rdacarrier
000753722 504__ $$aIncludes bibliographical references.
000753722 5050_ $$a1 -- Fibrosis: overview 2 -- Autoimmunity in systemic sclerosis: Overview 3 -- Endothelial progenitor cell 4 -- Animal models of systemic sclerosis 5 -- Genetics of Systemic Sclerosis 6 -- Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis 7 -- Interleukin-6 in the Pathogenesis of Systemic Sclerosis 8 -- Epigenetics 9 -- Transforming Growth Factor-€ and Connective Tissue Growth Factor 10 -- Endothelin 11 -- The Role of B cells in Systemic Sclerosis 12 -- Fli1 13 -- Biomarker 14 -- Autoantibodies in Systemic Sclerosis.
000753722 506__ $$aAccess limited to authorized users.
000753722 520__ $$aThis book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.
000753722 588__ $$aOnline resource; title from PDF title page (viewed February 9, 2016)
000753722 650_0 $$aSystemic scleroderma.
000753722 650_0 $$aSystemic scleroderma$$xResearch.
000753722 7001_ $$aTakehara, Kazuhiko,$$eeditor.
000753722 7001_ $$aFujimoto, Manabu,$$eeditor.
000753722 7001_ $$aKuwana, Masataka,$$eeditor.
000753722 77608 $$iPrint version:$$z9784431557074
000753722 852__ $$bebk
000753722 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-4-431-55708-1$$zOnline Access$$91397441.1
000753722 909CO $$ooai:library.usi.edu:753722$$pGLOBAL_SET
000753722 980__ $$aEBOOK
000753722 980__ $$aBIB
000753722 982__ $$aEbook
000753722 983__ $$aOnline
000753722 994__ $$a92$$bISE