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000753772 020__ $$a9783319278209$$q(electronic book)
000753772 020__ $$a3319278207$$q(electronic book)
000753772 020__ $$z9783319278186
000753772 0247_ $$a10.1007/978-3-319-27820-9$$2doi
000753772 035__ $$aSP(OCoLC)ocn938557326
000753772 035__ $$aSP(OCoLC)938557326
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000753772 049__ $$aISEA
000753772 050_4 $$aRD651
000753772 08204 $$a616.99407$$223
000753772 1001_ $$aRibatti, Domenico,$$d1956-$$eauthor.
000753772 24514 $$aThe role of microenvironment in the control of tumor angiogenesis$$h[electronic resource] /$$cDomenico Ribatti.
000753772 264_1 $$a[Cham] :$$bSpringer,$$c[2016]
000753772 264_4 $$c©2016
000753772 300__ $$a1 online resource
000753772 336__ $$atext$$btxt$$2rdacontent
000753772 337__ $$acomputer$$bc$$2rdamedia
000753772 338__ $$aonline resource$$bcr$$2rdacarrier
000753772 504__ $$aIncludes bibliographical references and index.
000753772 506__ $$aAccess limited to authorized users.
000753772 520__ $$aThis work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis. Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes. In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors. In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis. New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.
000753772 588__ $$aOnline resource; title from PDF title page (viewed February 12, 2016)
000753772 650_0 $$aTumors.
000753772 650_0 $$aPathology, Cellular.
000753772 77608 $$iPrint version:$$z9783319278186
000753772 852__ $$bebk
000753772 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-27820-9$$zOnline Access$$91397441.1
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000753772 980__ $$aEBOOK
000753772 980__ $$aBIB
000753772 982__ $$aEbook
000753772 983__ $$aOnline
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