The role of microenvironment in the control of tumor angiogenesis [electronic resource] / Domenico Ribatti.
2016
RD651
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Title
The role of microenvironment in the control of tumor angiogenesis [electronic resource] / Domenico Ribatti.
ISBN
9783319278209 (electronic book)
3319278207 (electronic book)
9783319278186
3319278207 (electronic book)
9783319278186
Published
[Cham] : Springer, [2016]
Copyright
©2016
Language
English
Description
1 online resource
Item Number
10.1007/978-3-319-27820-9 doi
Call Number
RD651
Dewey Decimal Classification
616.99407
Summary
This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis. Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes. In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors. In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis. New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.
Bibliography, etc. Note
Includes bibliographical references and index.
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Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (viewed February 12, 2016)
Available in Other Form
Print version: 9783319278186
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