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000753788 020__ $$a9784431558408$$q(electronic book)
000753788 020__ $$a4431558403$$q(electronic book)
000753788 020__ $$z9784431558385
000753788 0247_ $$a10.1007/978-4-431-55840-8$$2doi
000753788 035__ $$aSP(OCoLC)ocn938557479
000753788 035__ $$aSP(OCoLC)938557479
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000753788 24500 $$aMolecular science of fluctuations toward biological functions$$h[electronic resource] /$$cMasahide Terazima, Mikio Kataoka, Ryuichi Ueoka, Yuko Okamota, editors.
000753788 264_1 $$aTokyo :$$bSpringer,$$c[2016]
000753788 264_4 $$c©2016
000753788 300__ $$a1 online resource :$$billustrations.
000753788 336__ $$atext$$btxt$$2rdacontent
000753788 337__ $$acomputer$$bc$$2rdamedia
000753788 338__ $$aonline resource$$bcr$$2rdacarrier
000753788 504__ $$aIncludes bibliographical references.
000753788 5050_ $$aTime-resolved detection of protein fluctuations during reactions -- Pressure perturbation: A prime tool to study conformational substates and volume fluctuations of biomolecular assemblies -- Watching a signaling protein function in real time via picosecond time-resolved Laue crystallography -- NMR explorations of biomolecular systems with rapid conformational exchanges -- Site-specific incorporation of fluorescent nonnatural amino acids in-to proteins and its application to fluorescence analysis of proteins -- Unfoldomes and unfoldomics: introducing intrinsically disordered proteins -- Structure, dynamics and function of staphylococcal nuclease -- Theory of molecular recognition and structural fluctuation of biomolecules -- Structural fluctuations of proteins in folding and ligand docking studied by replica-exchange simulations -- Spatio-temporal fluctuations of protein folding in living cells -- Membrane-targeted nanotherapy with hybrid liposomes for cancer cells leading to apoptosis -- Anti-tumor complexes formed by oleic acid and molten globule intermediates of proteins.
000753788 506__ $$aAccess limited to authorized users.
000753788 520__ $$aIn this monograph, the importance of fluctuations for biological reactions is discussed from various points of view. Understanding the biological reactions at the molecular level is one of the major targets in many scientific fields, including not only basic biology but also physics, physical chemistry, and medical science. One of the key factors in the process is ℓ́ℓfluctuationℓ́ℓ. Thermal energy causes biological molecules to be in constant fluctuation even while they are carrying out their biological functions. How do biological systems overcome the thermal fluctuations to realize the physiologically relevant reactions? Scientists in a number of fieldsℓ́ℓphysics, chemistry, pharmacology, medicine, and othersℓ́ℓhave contributed chapters that elucidate the nature of the fluctuations and the relationship between fluctuations and biological functions. The fluctuations discussed in this volume are detected by the transient grating method, nuclear magnetic resonance, X-ray diffraction and scattering, and computer simulation, among other methods. The book presents various results of the studies of fluctuations in biological processes that were obtained with these methods by the leading scientists in their fields. .
000753788 588__ $$aOnline resource; title from PDF title page (viewed February 15, 2016).
000753788 650_0 $$aMolecular biology.
000753788 650_0 $$aBioorganic chemistry.
000753788 650_0 $$aBiophysics.
000753788 7001_ $$aTerazima, Masahide,$$eeditor.
000753788 7001_ $$aKataoka, Mikio,$$eeditor.
000753788 7001_ $$aUeoka, Ryuichi,$$eeditor.
000753788 7001_ $$aOkamoto, Yuko,$$eeditor.
000753788 77608 $$iPrint version:$$z9784431558385
000753788 852__ $$bebk
000753788 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-4-431-55840-8$$zOnline Access$$91397441.1
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