000753824 000__ 04655cam\a2200457Ii\4500
000753824 001__ 753824
000753824 005__ 20230306141522.0
000753824 006__ m\\\\\o\\d\\\\\\\\
000753824 007__ cr\cn\nnnunnun
000753824 008__ 160215t20162016sz\a\\\\ob\\\\001\0\eng\d
000753824 020__ $$a9783319246963$$q(electronic book)
000753824 020__ $$a3319246968$$q(electronic book)
000753824 020__ $$z9783319246949
000753824 0247_ $$a10.1007/978-3-319-24696-3$$2doi
000753824 035__ $$aSP(OCoLC)ocn939404910
000753824 035__ $$aSP(OCoLC)939404910
000753824 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dGW5XE$$dYDXCP$$dIDEBK$$dEBLCP$$dAZU$$dOCLCF$$dCDX$$dCOO
000753824 049__ $$aISEA
000753824 050_4 $$aQH581.2
000753824 08204 $$a571.6$$223
000753824 24504 $$aThe initiation of DNA replication in eukaryotes$$h[electronic resource] /$$cDaniel L. Kaplan, editor.
000753824 264_1 $$aCham :$$bSpringer,$$c[2016]
000753824 264_4 $$c©2016
000753824 300__ $$a1 online resource :$$bcolor illustrations
000753824 336__ $$atext$$btxt$$2rdacontent
000753824 337__ $$acomputer$$bc$$2rdamedia
000753824 338__ $$aonline resource$$bcr$$2rdacarrier
000753824 504__ $$aIncludes bibliographical references and index.
000753824 5050_ $$a1. Introduction to DNA replication initiation in eukaryotes -- 2. Choice of origins and replication timing control in yeast -- 3. Replication timing and initiation in metazoans.- 4. Replication timing gradients and origin activation -- 5. Genome wide localization of replication initiation factors -- 6. Genome scale analysis of metaozoan replication origins -- 7. Role of dormant origins in replication initiation -- 8. Centromeres and DNA replication initiation -- 9. Rif1 regulation of replication timing -- 10. Role of ORC in replication initiation.- 11. Licensing of replication origins- loading Mcm2-7 -- 12. Role of chromatin in replication initiation -- 13. Role of Mcm2-7 in replication initiation -- 14. Role of CDK in replication initiation -- 15. Role of DDK in replication initiation -- 16. Roles of Sld2, Sld3, and Dpb11 in replication initiation -- 17. Role of Mcm10 in replication initiation -- 18. Role of post-translational modifications in replication initiation -- 19. Assembly of the Cdc45-Mcm2-7-GINS complex, the replication helicase.- 20. Activity of the Cdc45-Mcm2-7-GINS complex, the replication helicase -- 21. Structure function studies of replication initiation factors -- 22. Pol-alpha activation and coupling with helicase unwinding -- 23. Replication initiation and DNA damage -- 24. Protein phosphatases and replication initiation -- 25. Spindle checkpoints and replication initiation.- 26. Protein degradation and replication initiation -- 27. Break-induced replication.- 27. Meier Gorlin syndrome -- 28. Replication Stress and Cancer.
000753824 506__ $$aAccess limited to authorized users.
000753824 520__ $$aEvery time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.
000753824 588__ $$aOnline resource; title from PDF title page (viewed February 16, 2016).
000753824 650_0 $$aEukaryotic cells.
000753824 650_0 $$aCytology.
000753824 650_0 $$aMolecular biology.
000753824 7001_ $$aKaplan, Daniel L.,$$eauthor,$$eeditor.
000753824 77608 $$iPrint version:$$z9783319246949
000753824 852__ $$bebk
000753824 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-24696-3$$zOnline Access$$91397441.1
000753824 909CO $$ooai:library.usi.edu:753824$$pGLOBAL_SET
000753824 980__ $$aEBOOK
000753824 980__ $$aBIB
000753824 982__ $$aEbook
000753824 983__ $$aOnline
000753824 994__ $$a92$$bISE