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000754070 020__ $$a9781493935093$$q(electronic book)
000754070 020__ $$a1493935097$$q(electronic book)
000754070 020__ $$z9781493935079
000754070 0247_ $$a10.1007/978-1-4939-3509-3$$2doi
000754070 035__ $$aSP(OCoLC)ocn944031720
000754070 035__ $$aSP(OCoLC)944031720
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000754070 08204 $$a660.6/5$$223
000754070 24500 $$aGenome editing$$h[electronic resource] :$$bthe next step in gene therapy /$$cToni Cathomen, Matthew Hirsch, Matthew Porteus, editors.
000754070 264_1 $$aNew York, NY :$$bSpringer,$$c2016.
000754070 300__ $$a1 online resource (xvi, 263 pages) :$$billustrations.
000754070 336__ $$atext$$btxt$$2rdacontent
000754070 337__ $$acomputer$$bc$$2rdamedia
000754070 338__ $$aonline resource$$bcr$$2rdacarrier
000754070 4901_ $$aAdvances in experimental medicine and biology,$$x0065-2598 ;$$vvolume 895
000754070 500__ $$aIncludes index.
000754070 5050_ $$a1. Gene Editing: Double-Strand Break Induced Gene Targeting and Mutagenesis 20 Years Later -- 2. The Development and Use of Zinc-Finger Nucleases -- 3.The Use and Development of TAL Effector Nucleases -- 4. Genome Editing for Neuromuscular Diseases -- 5. Phage Integrases for Genome Editing -- 6. Precise Genome Modification Using Triplex Forming Oligonucleotides and Peptide Nucleic Acids -- 7. Genome Editing by Aptamer-Guided Gene Targeting -- 8. Stimulation of AAV Gene Editing via DSB Repair -- 9. Engineered Nucleases and Trinucleotide Repeat Diseases -- 10. Using Engineered Nucleases to Create HIV-Resistant Cells -- 11. Strategies to Determine Off-Target Effects of Engineered Nucleases.
000754070 506__ $$aAccess limited to authorized users.
000754070 520__ $$aThis comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field. Genome Editing: The Next Step in Gene Therapy, the latest volume in the American Society of Gene and Cell Therapy series, deftly illuminates the potential of genetic engineering technology to eradicate today's deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology. .
000754070 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed March 7, 2016).
000754070 650_0 $$aGenetic engineering.
000754070 650_0 $$aGene therapy.
000754070 7001_ $$aCathomen, Toni,$$eeditor.
000754070 7001_ $$aHirsch, Matthew,$$eeditor.
000754070 7001_ $$aPorteus, Matthew H.,$$eeditor.
000754070 77608 $$iPrint version:$$z9781493935079
000754070 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 895.
000754070 852__ $$bebk
000754070 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-1-4939-3509-3$$zOnline Access$$91397441.1
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000754070 980__ $$aBIB
000754070 982__ $$aEbook
000754070 983__ $$aOnline
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