Therapeutic potentials of curcumin for Alzheimer disease [electronic resource] / Akhlaq A. Farooqui.
Farooqui, Akhlaq A., author.
2016
RM666.T88
Available Online

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Title Therapeutic potentials of curcumin for Alzheimer disease [electronic resource] / Akhlaq A. Farooqui.
Author Farooqui, Akhlaq A., author.
ISBN 9783319158891 (electronic book)
3319158899 (electronic book)
9783319158884
DOI https://doi.org/10.1007/978-3-319-15889-1
Published Cham : Springer, 2016.
Language English
Description 1 online resource (xix, 402 pages) : illustrations.
Other Standard Identifiers 10.1007/978-3-319-15889-1 doi
Call Number RM666.T88
Dewey Decimal Classification 615/.321
Summary Curcumin is a yellow-orange pigment obtained from the plant Curcuma longa. The powdered rhizome of this plant, called turmeric, is a common ingredient in curry powders and has a long history of use in traditional Asian medicine. Thus, curcumin has been used extensively in Ayurvedic medicine (Indian system of medicine) and Chinese traditional medicine for centuries as a antinociceptive, antiinflammatory, and antishock agent to relieve pain and inflammation. Epidemiological studies have revealed that in India, where dietary curcumin is consumed daily in the form of curry than in the United States, the morbidity rate attributed to Alzheimer disease (AD) for Indian elders (70-79 years old) is 4.4 times lower compared to the same age group of Americans. Furthermore, elderly healthy individuals who consume curry more frequently show better cognitive performance than senior who do not consume curry. Curcumin has been extensively investigated for treating AD over decades in animal model of AD, where curcumin crosses blood brain barrier and neural cell membranes and mediates its antioxidant, antiinflammatory, antiamyloidogenic , antiangiogenic, antiproliferative, antiapoptotic, metal chelating effects leading to retardation of signal transduction pathways associated with oxidative stress and neuroinflammation. Thus, curcumin fulfills the characteristics for an ideal neuroprotective agent for AD with its low toxicity, affordability, and easy accessibility. However, poor bioavailability of curcumin is the major hurdle for its more widespread use in animals and humans. The bioavailability of curcumin can be increased by encapsulation of curcumin into liposomes, cyclodextrin, curcumin conjugate with PLGA, complexation with phospholipids, and synthesis of curcumin analogs. This monograph is the first to describe neurochemical potentials of curcumin for the treatment of AD. This monograph presents readers with cutting edge and comprehensive information on the effect of curcumin on visceral organs and brain. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, nutritionists, and physicians, who are curious signal transduction processes associated with antioxidant, antiinflammatory, antiamyloidogenic , antiangiogenic, antiproliferative, and antiapoptotic effects of curcumin on the brain. .
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed March 9, 2016).
Available in Other Form Print version: 9783319158884
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Preface
Effect of long term consumption of high calorie diet and calorie restriction on human health
Neurochemical effects of long term consumption of high fat diet
Neurochemical effects of long term consumption of simple carbohydrates
Effects of long term consumption of animal proteins in the high calorie diet
Effect of soft drink consumption on human health
Contribution of salt in inducing biochemical changes in the brain
Importance and roles of fiber in the diet
Effects of the high calorie diet on the development of chronic visceral disease
Effects of long term consumption of high calorie diet on neurological disorders
Perspective and direction for future research: modification of high calorie diet needed for optimal health of human visceral and brain tissues
Index.

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