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000754115 020__ $$a9783319158891$$q(electronic book)
000754115 020__ $$a3319158899$$q(electronic book)
000754115 020__ $$z9783319158884
000754115 0247_ $$a10.1007/978-3-319-15889-1$$2doi
000754115 035__ $$aSP(OCoLC)ocn944178873
000754115 035__ $$aSP(OCoLC)944178873
000754115 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dIDEBK$$dN$T$$dEBLCP$$dAZU$$dYDXCP$$dCOO
000754115 049__ $$aISEA
000754115 050_4 $$aRM666.T88
000754115 08204 $$a615/.321$$223
000754115 1001_ $$aFarooqui, Akhlaq A.,$$eauthor.
000754115 24510 $$aTherapeutic potentials of curcumin for Alzheimer disease$$h[electronic resource] /$$cAkhlaq A. Farooqui.
000754115 264_1 $$aCham :$$bSpringer,$$c2016.
000754115 300__ $$a1 online resource (xix, 402 pages) :$$billustrations.
000754115 336__ $$atext$$btxt$$2rdacontent
000754115 337__ $$acomputer$$bc$$2rdamedia
000754115 338__ $$aonline resource$$bcr$$2rdacarrier
000754115 504__ $$aIncludes bibliographical references and index.
000754115 5050_ $$aPreface -- Effect of long term consumption of high calorie diet and calorie restriction on human health -- Neurochemical effects of long term consumption of high fat diet -- Neurochemical effects of long term consumption of simple carbohydrates -- Effects of long term consumption of animal proteins in the high calorie diet -- Effect of soft drink consumption on human health -- Contribution of salt in inducing biochemical changes in the brain -- Importance and roles of fiber in the diet -- Effects of the high calorie diet on the development of chronic visceral disease -- Effects of long term consumption of high calorie diet on neurological disorders -- Perspective and direction for future research: modification of high calorie diet needed for optimal health of human visceral and brain tissues -- Index.
000754115 506__ $$aAccess limited to authorized users.
000754115 520__ $$aCurcumin is a yellow-orange pigment obtained from the plant Curcuma longa. The powdered rhizome of this plant, called turmeric, is a common ingredient in curry powders and has a long history of use in traditional Asian medicine. Thus, curcumin has been used extensively in Ayurvedic medicine (Indian system of medicine) and Chinese traditional medicine for centuries as a antinociceptive, antiinflammatory, and antishock agent to relieve pain and inflammation. Epidemiological studies have revealed that in India, where dietary curcumin is consumed daily in the form of curry than in the United States, the morbidity rate attributed to Alzheimer disease (AD) for Indian elders (70-79 years old) is 4.4 times lower compared to the same age group of Americans. Furthermore, elderly healthy individuals who consume curry more frequently show better cognitive performance than senior who do not consume curry. Curcumin has been extensively investigated for treating AD over decades in animal model of AD, where curcumin crosses blood brain barrier and neural cell membranes and mediates its antioxidant, antiinflammatory, antiamyloidogenic , antiangiogenic, antiproliferative, antiapoptotic, metal chelating effects leading to retardation of signal transduction pathways associated with oxidative stress and neuroinflammation. Thus, curcumin fulfills the characteristics for an ideal neuroprotective agent for AD with its low toxicity, affordability, and easy accessibility. However, poor bioavailability of curcumin is the major hurdle for its more widespread use in animals and humans. The bioavailability of curcumin can be increased by encapsulation of curcumin into liposomes, cyclodextrin, curcumin conjugate with PLGA, complexation with phospholipids, and synthesis of curcumin analogs. This monograph is the first to describe neurochemical potentials of curcumin for the treatment of AD. This monograph presents readers with cutting edge and comprehensive information on the effect of curcumin on visceral organs and brain. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, nutritionists, and physicians, who are curious signal transduction processes associated with antioxidant, antiinflammatory, antiamyloidogenic , antiangiogenic, antiproliferative, and antiapoptotic effects of curcumin on the brain. .
000754115 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed March 9, 2016).
000754115 650_0 $$aTurmeric$$xTherapeutic use.
000754115 650_0 $$aAlzheimer's disease$$xDiet therapy.
000754115 650_0 $$aPhytochemicals$$xTherapeutic use.
000754115 650_0 $$aPlant polyphenols$$xTherapeutic use.
000754115 77608 $$iPrint version:$$z9783319158884
000754115 852__ $$bebk
000754115 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-15889-1$$zOnline Access$$91397441.1
000754115 909CO $$ooai:library.usi.edu:754115$$pGLOBAL_SET
000754115 980__ $$aEBOOK
000754115 980__ $$aBIB
000754115 982__ $$aEbook
000754115 983__ $$aOnline
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