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1. Introduction: The holobiont imperative
2. Major events in the evolution of Planet Earth : some origin stories
3. The diversity of animal life : introduction to early emerging metazoans
4. Phylosymbiosis : novel genomic approaches discover the holobiont
5. Negotiations between evolving animals and symbionts
6. Role of symbionts in evolutionary processes
7. The Hydra holobiont : a tale of several symbiotic lineages
8. Corals
9. Bleaching as an obvious dysbiosis in corals
10. The hidden impact of viruses
11. Seeking a holistic view of early emerging metazoans : the power of modularity.

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