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000754317 019__ $$a945873665
000754317 020__ $$a9783319238982$$q(electronic book)
000754317 020__ $$a3319238981$$q(electronic book)
000754317 020__ $$z9783319238975
000754317 0247_ $$a10.1007/978-3-319-23898-2$$2doi
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000754317 049__ $$aISEA
000754317 050_4 $$aQR360
000754317 08204 $$a579.2$$223
000754317 24500 $$aQuasispecies$$h[electronic resource] :$$bfrom theory to experimental systems /$$cEsteban Domingo, Peter Schuster, editors.
000754317 264_1 $$aCham :$$bSpringer,$$c2016.
000754317 300__ $$a1 online resource (xiv, 358 pages).
000754317 336__ $$atext$$btxt$$2rdacontent
000754317 337__ $$acomputer$$bc$$2rdamedia
000754317 338__ $$aonline resource$$bcr$$2rdacarrier
000754317 4901_ $$aCurrent topics in microbiology and immunology,$$x0070-217X ;$$vvolume 392
000754317 500__ $$aIncludes indexes.
000754317 5050_ $$aWhat is a quasispecies?- Historical origins and current scope -- The nucleation of semantic information in prebiotic matter -- Evolution of RNA-based networks -- Quasispecies on fitness landscapes -- Mathematical models of quasispecies theory and exact results for the dynamics -- Theoretical Models of Generalized Quasispecies -- Theories of lethal mutagenesis: from error catastrophe to lethal defection -- Estimating fitness of viral quasispecies from next-generation sequencing data -- Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models -- Cooperative Interaction within RNA Virus Mutant Spectra -- Arenavirus Quasispecies And Their Biological Implications -- Models of viral population dynamics -- Fidelity variants and RNA quasispecies -- Antiviral strategies based on lethal mutagenesis and error threshold.
000754317 506__ $$aAccess limited to authorized users.
000754317 520__ $$aThis volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology. .
000754317 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed March 23, 2016).
000754317 650_0 $$aVirology.
000754317 650_0 $$aRNA viruses.
000754317 650_0 $$aSpecies.
000754317 7001_ $$aDomingo, Esteban,$$eeditor.
000754317 7001_ $$aSchuster, Peter,$$eeditor.
000754317 77608 $$iPrint version:$$z9783319238975
000754317 830_0 $$aCurrent topics in microbiology and immunology ;$$v392.
000754317 852__ $$bebk
000754317 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-23898-2$$zOnline Access$$91397441.1
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000754317 980__ $$aEBOOK
000754317 980__ $$aBIB
000754317 982__ $$aEbook
000754317 983__ $$aOnline
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