Quasispecies [electronic resource] : from theory to experimental systems / Esteban Domingo, Peter Schuster, editors.
Domingo, Esteban, editor.; Schuster, Peter, editor.
2016
QR360
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Title
Quasispecies [electronic resource] : from theory to experimental systems / Esteban Domingo, Peter Schuster, editors.
ISBN
9783319238982 (electronic book)
3319238981 (electronic book)
9783319238975
DOI
https://doi.org/10.1007/978-3-319-23898-2
Published
Cham : Springer, 2016.
Language
English
Description
1 online resource (xiv, 358 pages).
Item Number
10.1007/978-3-319-23898-2 doi
Call Number
QR360
Dewey Decimal Classification
579.2
Summary
This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology. .
Note
Includes indexes.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed March 23, 2016).
Added Author
Domingo, Esteban, editor.
Schuster, Peter, editor.
Series
Current topics in microbiology and immunology ; 392.
Available in Other Form
Print version: 9783319238975
Linked Resources
Online Access
Record Appears in
Online Resources > Ebooks
All Resources
What is a quasispecies?- Historical origins and current scope
The nucleation of semantic information in prebiotic matter
Evolution of RNA-based networks
Quasispecies on fitness landscapes
Mathematical models of quasispecies theory and exact results for the dynamics
Theoretical Models of Generalized Quasispecies
Theories of lethal mutagenesis: from error catastrophe to lethal defection
Estimating fitness of viral quasispecies from next-generation sequencing data
Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models
Cooperative Interaction within RNA Virus Mutant Spectra
Arenavirus Quasispecies And Their Biological Implications
Models of viral population dynamics
Fidelity variants and RNA quasispecies
Antiviral strategies based on lethal mutagenesis and error threshold.

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