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000754350 019__ $$a945873983
000754350 020__ $$a9783319275116$$q(electronic book)
000754350 020__ $$a3319275119$$q(electronic book)
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000754350 0247_ $$a10.1007/978-3-319-27511-6$$2doi
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000754350 049__ $$aISEA
000754350 050_4 $$aQP301
000754350 08204 $$a612.7$$223
000754350 24500 $$aGrowth factors and cytokines in skeletal muscle development, growth, regeneration and disease$$h[electronic resource] /$$cJason White, Gayle Smith, editors.
000754350 264_1 $$aSwitzerland :$$bSpringer,$$c2016.
000754350 264_4 $$c©2016
000754350 300__ $$a1 online resource.
000754350 336__ $$atext$$btxt$$2rdacontent
000754350 337__ $$acomputer$$bc$$2rdamedia
000754350 338__ $$aonline resource$$bcr$$2rdacarrier
000754350 4901_ $$aAdvances in experimental medicine and biology,$$vvolume 900
000754350 504__ $$aIncludes bibliographical references and index.
000754350 5050_ $$aIntroduction; Contents; Chapter 1: Hepatocyte Growth Factor and Satellite Cell Activation; 1.1 Introduction; 1.2 Satellite Cell Activation; 1.3 Myogenic Cell Motility; 1.4 Zebrafish Single-Fiber Studies of Satellite Cell Activation; 1.5 Re-defining the Impact of Age on Satellite Cell Activation and Muscle-Growth Capacity; 1.6 Integrating Growth, Satellite-Cell Behaviour and Cytoskeletal Development; 1.7 Conclusion; References; Chapter 2: Cytokine Mediated Control of Muscle Stem Cell Function; 2.1 Introduction; 2.1.1 Skeletal Muscle; 2.2 Satellite Cells; 2.3 The Role of Satellite Cells
000754350 5058_ $$a2.3.1 Muscle Regeneration and Growth2.3.2 Exercise and Adaptation; 2.3.3 Muscle Pathology; 2.4 Myogenic Regulatory Factors; 2.5 Interleukins and Their Role in Muscle Growth and Regeneration; 2.6 Interleukins and Myogenesis; 2.6.1 Proliferation; 2.6.2 Differentiation; 2.6.3 Interleukins Derived Macrophages and Myogenesis; 2.7 Conclusion; References; Chapter 3: The Role of Leukemia Inhibitory Factor Receptor Signaling in Skeletal Muscle Growth, Injury and Disease; 3.1 Introduction; 3.2 Varied Sources of LIFR Cytokines Regulating Muscle and Peripheral Homeostasis
000754350 5058_ $$a3.3 LIFR Is Involved in Muscle Development Predominantly Via Neurotrophic Effects3.4 Indirect and Direct Effects of LIFR Cytokines Regulate Adult Muscle Cell Homeostasis; 3.5 Metabolic Functions of LIFR Cytokines; 3.6 Potential for LIFR Cytokines in Treating Muscular Dystrophies; 3.7 Conclusions; References; Chapter 4: Function of Membrane-Associated Proteoglycans in the Regulation of Satellite Cell Growth; 4.1 Introduction; 4.2 Skeletal Muscle Growth and Development; 4.3 Extracellular Matrix; 4.4 Cell Membrane-Associated Proteoglycans; 4.4.1 Syndecans; 4.4.2 Glypican-1; 4.4.3 Betaglycan
000754350 5058_ $$a4.4.4 CD444.4.5 Neuropilin; 4.5 Cytokines and Growth Factors Affecting Muscle Development and Growth; 4.5.1 Interleukin-6; 4.5.2 Leukemia Inhibitory Factor; 4.5.3 Tumor Necrosis Factor-α; 4.5.4 Hepatocyte Growth Factor; 4.5.5 Insulin-Like Growth Factors; 4.5.6 Transforming Growth Factor-Beta; 4.6 Conclusions; References; Chapter 5: The TGF-β Signalling Network in Muscle Development, Adaptation and Disease; 5.1 Introduction; 5.2 The TGF-β Signalling Network in Overview; 5.2.1 Ligand Synthesis and Secretion
000754350 5058_ $$a5.2.2 Prodomains Control TGF-β Ligand Activity and Localisation in the Extracellular Matrix5.2.3 TGF-β Family Members Target Specific Receptor Complexes and Transcription Factors; 5.2.4 Extracellular Regulation of TGF-β Signalling; 5.3 The Role of TGF-β Signalling in Skeletal Muscle Development and Homeostasis; 5.3.1 Skeletal Muscle Development; 5.3.2 Myostatin as a Regulator of Myogenesis; 5.3.3 Myostatin as a Regulator of Muscle Fibre Size; 5.3.4 Other TGF-β Proteins as Regulators of Muscle Development and Maturation; 5.4 The Role of TGF-β Signalling in Post-natal Muscle Regeneration
000754350 506__ $$aAccess limited to authorized users.
000754350 520__ $$aThis book describes the diverse roles that growth factors and cytokines play in skeletal muscle. The extracellular environment has profound effects on the biology of skeletal muscle. The soluble portion of this environment includes a rich milieu of growth factors and cytokines which have been shown to regulate virtually all facets of the response of skeletal muscle to external stimuli, whether it be exercise induced metabolic shifts, remodeling in response to trauma or loading of the ongoing pathology associated with neuromuscular disease. The chapters included in this work illustrate growth factors that directly affect skeletal muscle cells and those which influence non-muscle cells that contribute to the biology of skeletal muscle as a whole tissue. The current state of the art, with the advent of systems biology, allows for the delineation of signaling networks which are regulated by suites of growth factors. This is in stark contrast to early more traditional studies, which only examined the effects of isolated growth factors on the activity of skeletal muscle precursor cells in tissue culture. The work presented in this volume ranges from reviewing and analyzing the roles of individual growth factors in detail, to the complex interplay of multiple soluble factors in the control of muscle functional, and dysfunctional states. The material covered in this volume will particularly suit readers from a range of research fields spanning general muscle biology and physiology, and those working on diseases and conditions affecting skeletal muscle both directly and indirectly.
000754350 588__ $$aOnline resource; title from PDF title page (viewed March 29, 2016).
000754350 650_0 $$aMuscles$$xRegeneration.
000754350 650_0 $$aMusculoskeletal system.
000754350 650_0 $$aMuscle cells.
000754350 7001_ $$aWhite, Jason,$$eeditor.
000754350 7001_ $$aSmythe, Gayle,$$eauthor.
000754350 77608 $$iPrint version:$$z9783319275093
000754350 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 900.
000754350 852__ $$bebk
000754350 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-27511-6$$zOnline Access$$91397441.1
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000754350 980__ $$aBIB
000754350 982__ $$aEbook
000754350 983__ $$aOnline
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