Modeling in biopharmaceutics, pharmacokinetics, and pharmacodynamics [electronic resource] : homogeneous and heterogeneous approaches / Panos Macheras, Athanassios Iliadis.
Macheras, P. (Panos), author.; Iliadis, Athanassios, author.
2016
RM301.5 .M33 2016eb
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Title Modeling in biopharmaceutics, pharmacokinetics, and pharmacodynamics [electronic resource] : homogeneous and heterogeneous approaches / Panos Macheras, Athanassios Iliadis.
Author Macheras, P. (Panos), author.
Edition Second edition.
ISBN 9783319275987 (electronic book)
3319275984 (electronic book)
3319275968
9783319275963
DOI https://doi.org/10.1007/978-3-319-27598-7
Published New York : Springer, [2016]
Copyright ©2016
Language English
Description 1 online resource (xxii, 483 pages).
Item Number 10.1007/978-3-319-27598-7 doi
Call Number RM301.5 .M33 2016eb
Dewey Decimal Classification 615/.7
Summary The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology. Reviews of the first edition: "This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007) "These authors are the unique (or sole) contributors in this area that are working on these questions and bring a special expertise to the field that is now being recognized as essential to understanding biological system and kinetic/dynamic characteristics in drug development...This text is an essential primer for those who would envision the incorporation of heterogeneous approaches to systems where homogeneous approaches are not sufficient to describe the system." (Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006).
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Iliadis, Athanassios, author.
Series Interdisciplinary applied mathematics ; v. 30.
Available in Other Form Modeling in biopharmaceutics, pharmacokinetics and pharmacodynamics.
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Record Appears in Online Resources > Ebooks
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Part I: Basic Concepts
The Geometry of Nature
Diffusion and Kinetics
Nonlinear Dynamics
Part II: Modeling in Biopharmaceutics
Drug Release
Drug Dissolution
Oral Drug Absorption
Part III: Modeling in Pharmacokinetics
Empirical Models
Deterministic Compartmental Models
Fractional Pharmacokinetics
Modeling and Simulation in Bioequivalence
Stochastic Compartmental Models
Part IV: Modeling in Pharmacodynamics
Classical Pharmacodynamics
Nonclassical Pharmacodynamics
Appendices.

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