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000754501 019__ $$a945948095$$a946786120
000754501 020__ $$a9783319289144$$q(electronic book)
000754501 020__ $$a3319289144$$q(electronic book)
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000754501 0247_ $$a10.1007/978-3-319-28914-4$$2doi
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000754501 050_4 $$aRM301.25
000754501 08204 $$a615.1072$$223
000754501 24500 $$aNew approaches to drug discovery$$h[electronic resource] /$$cUlrich Nielsch, Ulrike Fuhrmann, Stefan Jaroch, editors.
000754501 264_1 $$aSwitzerland :$$bSpringer,$$c[2016]
000754501 300__ $$a1 online resource :$$billustrations.
000754501 336__ $$atext$$btxt$$2rdacontent
000754501 337__ $$acomputer$$bc$$2rdamedia
000754501 338__ $$aonline resource$$bcr$$2rdacarrier
000754501 347__ $$atext file$$bPDF$$2rda
000754501 4901_ $$aHandbook of experimental pharmacology ;$$vvolume 232
000754501 504__ $$aIncludes bibliographical references and index.
000754501 5050_ $$aPreface -- Part 1. Historical View -- Drug discovery in the past and today.Part 2. Target Discovery -- Emerging target families: intractable targets. In vivo target validation especially for biological targets. HR RNAi/High Content analysis -- Part 3. Lead generation and Optimization -- Sources for leads: natural products, libraries. Screening: assays, readout, technology. Impact of structural biology, fragment based screening/Virtual screening. Predictive in silico tools of compound properties. High throughput synthesis. New compound classes: Protein-Protein Interaction. Sources for biological leads/Screening of biologicals -- Part 4. Test systems for Efficacy and Safety -- In vitro / Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impact of biomarkers/personalized medicine. Simulating in vivo drug effects.
000754501 506__ $$aAccess limited to authorized users.
000754501 520__ $$aThis volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.
000754501 588__ $$aOnline resource; title from PDF title page (viewed April 5, 2016).
000754501 650_0 $$aDrug development.
000754501 650_0 $$aPharmacology.
000754501 650_0 $$aPharmacy$$xResearch.
000754501 650_0 $$aClinical biochemistry.
000754501 7001_ $$aNielsch, Ulrich,$$eeditor.
000754501 7001_ $$aFuhrmann, U.$$q(Ulrike),$$d1959-$$eeditor.
000754501 7001_ $$aJaroch, S.$$q(Stefan),$$eeditor.
000754501 77608 $$iPrint version:$$z9783319289120
000754501 830_0 $$aHandbook of experimental pharmacology ;$$vv. 232.
000754501 852__ $$bebk
000754501 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-28914-4$$zOnline Access$$91397441.1
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