The genetics of type 2 diabetes and related traits [electronic resource] : biology, physiology and translation / Jose C. Florez, editor.
Florez, Jose C., editor.
2016
RC662.18
Available Online

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Title The genetics of type 2 diabetes and related traits [electronic resource] : biology, physiology and translation / Jose C. Florez, editor.
ISBN 9783319015743 (electronic book)
3319015745 (electronic book)
9783319015736
DOI https://doi.org/10.1007/978-3-319-01574-3
Published Switzerland : Springer, [2016]
Copyright ©2016
Language English
Description 1 online resource
Other Standard Identifiers 10.1007/978-3-319-01574-3 doi
Call Number RC662.18
Dewey Decimal Classification 616.4624042
Summary This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes. The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future. <.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (viewed April 19, 2016).
Added Author Florez, Jose C., editor.
Available in Other Form Print version: 9783319015736
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Part I Genetic Discovery
Part II Interpretation and Data Integration
Part III From Association to Function
Part IV Clinical Translation. .

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