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000755075 019__ $$a948632110
000755075 020__ $$a9781493936120$$q(electronic book)
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000755075 0247_ $$a10.1007/978-1-4939-3612-0$$2doi
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000755075 08204 $$a571.9/36$$223
000755075 24500 $$aMitochondria and cell death$$h[electronic resource] /$$cDavid M. Hockenbery, editor.
000755075 264_1 $$aNew York, NY :$$bHumana Press,$$c2016.
000755075 300__ $$a1 online resource (xii, 232 pages) :$$billustrations.
000755075 336__ $$atext$$btxt$$2rdacontent
000755075 337__ $$acomputer$$bc$$2rdamedia
000755075 338__ $$aonline resource$$bcr$$2rdacarrier
000755075 4901_ $$aCell death in biology and diseases
000755075 500__ $$aIncludes index.
000755075 5050_ $$aPreface -- 1.Lethal and non-lethal functions of the permeability transition pore -- 2.Mitochondrial Calcium and Ischemia-Reperfusion Injury in Heart -- 3.Mislocalization of mitochondrial intermembrane space proteins -- 4.Bcl-2 protein interplay on the outer mitochondrial membrane -- 5.Remodeling of Mitochondria in Apoptosis -- 6.Physiologic and Pathologic Functions of Mitochondrial ROS -- 7.Mitochondrial Mutagenesis in Cancer -- 8.Mitochondrial UPR in cancer -- 9.Mitochondrial signaling -- 10.Mitochondria and antiviral immunity -- 11.Mitochondrial permeabilization from lethality to vitality -- Index.
000755075 506__ $$aAccess limited to authorized users.
000755075 520__ $$aThis volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material. Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology, as well as those interested in the study of mitochondria and cell biology.
000755075 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed May 4, 2016).
000755075 650_0 $$aCell death.
000755075 650_0 $$aMitochondria.
000755075 650_0 $$aMitochondrial pathology.
000755075 7001_ $$aHockenbery, David M.$$eeditor.
000755075 77608 $$iPrint version:$$z1493936107$$z9781493936106$$w(OCoLC)932385659
000755075 830_0 $$aCell death in biology and diseases.
000755075 852__ $$bebk
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