Interleukin-27 [electronic resource] : biological properties and clinical application / Marek Jankowski, Tomasz Wandtke.
Jankowski, Marek, author.; Wandtke, Tomasz, author.
2016
QR185.8.I56
Available Online

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Title Interleukin-27 [electronic resource] : biological properties and clinical application / Marek Jankowski, Tomasz Wandtke.
Author Jankowski, Marek, author.
ISBN 9783319396644 (electronic book)
3319396641 (electronic book)
9783319396620
Published Switzerland : Springer, 2016.
Language English
Description 1 online resource (vi, 86 pages) : color illustrations.
Call Number QR185.8.I56
Dewey Decimal Classification 571.9/6
Summary This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed May 20, 2016).
Added Author Wandtke, Tomasz, author.
Series SpringerBriefs in immunology.
Available in Other Form Interleukin-27 : biological properties and clinical application.
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
IL-27: Structure, Regulation and Variability
IL-27: A Key Player in Immune Regulation
IL-27 in Health and Disease.

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