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000755450 019__ $$a951222057
000755450 020__ $$a9783319322322$$q(electronic book)
000755450 020__ $$a331932232X$$q(electronic book)
000755450 020__ $$z9783319322308
000755450 035__ $$aSP(OCoLC)ocn950459050
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000755450 049__ $$aISEA
000755450 050_4 $$aRM301.4
000755450 08204 $$a615.3/298$$223
000755450 1001_ $$aRosales-Mendoza, Sergio,$$eauthor.
000755450 24510 $$aAlgae-based biopharmaceuticals$$h[electronic resource] /$$cSergio Rosales-Mendoza.
000755450 264_1 $$aSwitzerland :$$bSpringer,$$c2016.
000755450 300__ $$a1 online resource (x, 166 pages) :$$billustrations.
000755450 336__ $$atext$$btxt$$2rdacontent
000755450 337__ $$acomputer$$bc$$2rdamedia
000755450 338__ $$aonline resource$$bcr$$2rdacarrier
000755450 504__ $$aIncludes bibliographical references and index.
000755450 5050_ $$aThe Biopharmaceuticals Field and Algae as Expression Hosts -- Genetic Engineering Approaches for Algae -- Algae-made Vaccines Targeting Human Diseases -- Algae-made Vaccines Targeting Animal Pathogens -- Algae-made Antibodies and Immunotoxins -- Algae-made Cytokines and Growth Factors -- Other Biopharmaceuticals Produced in Algae -- Algae-made Nutraceuticals -- Perspectives for the Algae-made Biopharmaceuticals Field.
000755450 506__ $$aAccess limited to authorized users.
000755450 520__ $$aThis book constitutes a key reference on the use of algae in the BFs production field; providing an updated outlook on the achievements accomplished thus far and transmitting a prospective view for this biotechnological application. This book provides a detailed description of the technology as well as an updated outlook of the strides achieved thus far in the field of algae-based biopharmaceuticals. Algae constitute attractive expression hosts for the production of recombinant proteins with medical applications. Among the features that make them attractive candidates are: low cost, fast growth, wide biosynthetic capacity, and absence of human pathogens; which constitute substantial advantages with respect to bacterial and mammalian systems. First, the features of algae as convenient hosts for the production of BFs are analyzed in terms of production costs, biosynthetic capacity, and safety (Chapter 1). Second, the genetic engineering tools for algae-species are described. Nuclear and chloroplast-based expression approaches are analyzed and compared in terms of biosynthetic advantages, gene expression complexity, and DNA transfer approaches (Chapter 2). In the following sections, chapters 3 to 7, the state of the art on producing distinct types of BFs in algae species is presented. Although this book is mainly focused on BFs, considering that the production of compounds with health-promoting properties are achieved using genetically-engineered algae strains, chapter 8 deals with nutraceuticals. In the ninth chapter, the developments reported thus far are placed in perspective and challenges for the field are discussed. Critical future prospects comprise the following: optimizing large-scale production in bioreactors, implementing glycoengineering approaches, optimizing nuclear expression, exploring new approaches for oral delivery, and implementing regulatory frameworks to accomplish technology transfer and regulatory approval of algae-made BFs.
000755450 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed May 31, 2016).
000755450 650_0 $$aBiopharmaceutics.
000755450 650_0 $$aAlgae$$xBiotechnology.
000755450 650_0 $$aPharmaceutical biotechnology.
000755450 77608 $$iPrint version:$$aRosales-Mendoza, Sergio$$tAlgae-Based Biopharmaceuticals$$dCham : Springer International Publishing,c2016$$z9783319322308
000755450 852__ $$bebk
000755450 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-32232-2$$zOnline Access$$91397441.1
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000755450 980__ $$aEBOOK
000755450 980__ $$aBIB
000755450 982__ $$aEbook
000755450 983__ $$aOnline
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