System engineering approach to planning anticancer therapies [electronic resource] / Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz.
Świerniak, Andrzej, author.; Kimmel, Marek, 1959- author.; Smieja, Jaroslaw, author.; Puszynski, Krzysztof, author.; Psiuk-Maksymowicz, Krzysztof, author.
2016
RC270.8
Available Online

Linked e-resources

Linked Resource Online Access
Concurrent users Unlimited
Authorized users Authorized users
Document Delivery Supplied Can lend chapters, not whole ebooks

Details

Title System engineering approach to planning anticancer therapies [electronic resource] / Andrzej Świerniak, Marek Kimmel, Jaroslaw Smieja, Krzysztof Puszynski, Krzysztof Psiuk-Maksymowicz.
ISBN 9783319280950 (electronic book)
3319280953 (electronic book)
9783319280936
Published Switzerland : Springer, 2016.
Language English
Description 1 online resource (ix, 235 pages) : illustrations.
Call Number RC270.8
Dewey Decimal Classification 616.99/406
Summary This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors' extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed May 27, 2016).
Added Author Świerniak, Andrzej, author.
Kimmel, Marek, 1959- author.
Smieja, Jaroslaw, author.
Puszynski, Krzysztof, author.
Psiuk-Maksymowicz, Krzysztof, author.
Available in Other Form System Engineering Approach to Planning Anticancer Therapies
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Introduction
Cell Cycle as an Object of Control
Therapy Optimization in Population Dynamics Models
Structured Models and Their Use in Modeling Anticancer Therapies
Signaling Pathways Dynamics and Cancer Treatment
Model Identification and Parameter Estimation
Appendixes: Stability and Controllability of Dynamical Systems
Pontryagin Maximum Principle and Optimal Control
Bifurcation Analysis
Numerical Implementation of the Runge Kutta and Gillespie Methods.

Browse Subjects

Show more subjects...

Statistics

from
to
Export