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000755601 020__ $$a9783319328058$$q(electronic book)
000755601 020__ $$a3319328050$$q(electronic book)
000755601 020__ $$z9783319328041
000755601 035__ $$aSP(OCoLC)ocn950967846
000755601 035__ $$aSP(OCoLC)950967846
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000755601 24500 $$aProtein targeting compounds$$h[electronic resource] :$$bprediction, selection and activity of specific inhibitors /$$cThomas Böldicke, editor.
000755601 264_1 $$aCham :$$bSpringer,$$c2016.
000755601 300__ $$a1 online resource.
000755601 336__ $$atext$$btxt$$2rdacontent
000755601 337__ $$acomputer$$bc$$2rdamedia
000755601 338__ $$aonline resource$$bcr$$2rdacarrier
000755601 4901_ $$aAdvances in experimental medicine and biology ;$$vvolume 917
000755601 500__ $$aIncludes index.
000755601 504__ $$aIncludes bibliographical references and index.
000755601 5050_ $$aIntroduction -- Part I Methods of Structure Prediction -- Chapter 1 In Silico Prediction of Target-Inhibitor Interactions -- Part II Antibodies -- Chapter 2 Antibodies and Selection of Monoclonal Antibodies -- Chapter 3 Selection of Recombinant Human Antibodies -- Chapter 4 Selection of Recombinant Human Antibodies against Toxins and Viruses -- Chapter 5 Recent Advances with ER Targeted Intrabodies -- Chapter 6 Therapeutic Blocking Antibodies against Oncogenic Receptors and Growth Factors -- Chapter 7 Synthetic Cystine-Knot Miniproteins-Valuable Scaffolds for Polypeptide Engineering -- Part III Peptides, Small Molecules and Aptamers -- Chapter 8 Peptides and Peptide Analogs to Inhibit Protein -- Chapter 9 Allosteric Modulators of the Class A G Protein coupled Receptors -- Chapter 10 Phosphatases: Their Roles in Cancer and their Chemical Modulators -- Chapter 11 Selection and Application of Aptamers and Intramers -- Part IV Angiogenesis Inhibitors -- Chapter 12 Inhibitors of Angiogenesis.
000755601 506__ $$aAccess limited to authorized users.
000755601 520__ $$aThis book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions. Key aspects of this book are: - Selection strategies for monoclonal and recombinant human antibodies - Selection strategies for ER intrabodies, peptides and aptamers - Examples of the most efficient inhibitors and their applications in protein biochemistry and cell biology - Antibodies for cancer therapy and inhibitors of angiogenesis. The book will be of great interest to scientists and students working in the life sciences on all areas related to protein biology. The variety of methods to modulate the activities of specific proteins which are introduced here will be of great benefit to the reader who is interested in general protein research or to readers who have very specific protein related questions.
000755601 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed June 1, 2016).
000755601 650_0 $$aProteins$$xSynthesis$$xInhibitors.
000755601 77608 $$iPrint version:$$tProtein targeting compounds : prediction, selection and activity of specific inhibitors.$$dCham, Switzerland : Springer, c2016$$z9783319328041
000755601 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 917.
000755601 852__ $$bebk
000755601 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-32805-8$$zOnline Access$$91397441.1
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000755601 980__ $$aBIB
000755601 982__ $$aEbook
000755601 983__ $$aOnline
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