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Intro; Preface; Acknowledgements; Contents; Contributors; Chapter 1: Depressive Disorders: Prevalence, Costs, and Theories; Chapter 2: Traditional and Novel Possible Targets for Antidepressant Drugs; Chapter 3: Cell-Based Systems of Depression: An Overview; Chapter 4: Animal Models of Depression; Chapter 5: Prevalence of Use of Herbal Medicines and Complementary and Alternative Medicine in Europe; Chapter 6: Medicinal Plants from Countries of Former USSR Used for Treatment of Depression; Chapter 7: Chinese Herbal Medicine Used Against Depression in China

Chapter 8: Antidepressant Medicinal Plants and Compounds Used in Traditional Medicines in North AmericaChapter 9: Antidepressant Plant Species from the Portuguese-Speaking African Countries (PALOP); Chapter 10: Oceania: Antidepressant Medicinal Plants; Chapter 11: Novel Drug Delivery Systems for Herbal Antidepressants; Chapter 12: Future Strategies for the Treatment of Depression; Index; 1.1 Introduction; 1.2 Prevalence; 1.3 Economic Burden; 1.4 Theories of Depression; 1.5 Conclusions; References; 2.1 Introduction; 2.2 Brief Historical Overview of Antidepressant Drug Development

2.3 Current Antidepressant Drugs: Mechanisms of Action2.4 Second-Generation Dual-Action Antidepressants; 2.5 Future Antidepressants: Targets of Action; 2.6 Conclusions; References; 3.1 Introduction; 3.2 Mechanisms of Depression: Hypothesis; 3.3 Neuronal Cell Models for Depression; 3.4 Glial Cell Cultures; 3.5 Conclusions and Future Directions; References; 4.1 Introduction; 4.2 Study of Depression in Rodents; 4.3 Endophenotypes in Animal Models of Depression; 4.4 Experimental Models of Depression; 4.5 Advantages of Experimental Models of Depression; 4.6 Limitations of Animal Models

4.7 ConclusionReferences; 5.1 Introduction; 5.2 Search Methods; 5.3 References; 5.4 Hypericum perforatum L.; 5.5 References; 5.6 Valeriana officinalis L..; 5.7 References; 5.8 Ocimum basilicum L.; 5.9 References; 5.10 Melissa officinalis L.; 5.11 References; 5.12 Tilia sp..; 5.13 References; 5.14 Verbena officinalis L.; 5.15 References; 6.1 Introduction; 6.2 Search Methods; 6.3 References; 6.4 Hypericum perforatum L.; 6.5 References; 6.6 Eleutherococcus senticosus (Rupr et Maxim.) Maxim; 6.7 References; 6.8 Leonurus cardiaca L; 6.9 References

6.10 Leonurus turkestanicus V.I. Kreczetovicz and Kuprianova6.11 References; 6.12 Nepeta cataria L; 6.13 References; 6.14 Oplopanax elatus (Nakai) Nakai; 6.15 References; 6.16 Patrinia intermedia (Hornem.) Roem et Schult; 6.17 References; 6.18 Rhaponticum carthamoides (Willd.) Iljin; 6.19 References; 7.1 Introduction; 7.2 References; 7.3 Acanthopanax senticosus (Rupr. et Maxim.) Harms; 7.4 References; 7.5 Acorus tatarinowii Schott; 7.6 References; 7.7 Allium macrostemon Bunge; 7.8 References; 7.9 Aloe barbadensis Miller; 7.10 References; 7.11 Centella asiatica (L.) Urban; 7.12 References

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