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000755763 019__ $$a951595254
000755763 020__ $$a9783319283050$$q(electronic book)
000755763 020__ $$a3319283057$$q(electronic book)
000755763 020__ $$z9783319283036
000755763 035__ $$aSP(OCoLC)ocn951434329
000755763 035__ $$aSP(OCoLC)951434329$$z(OCoLC)951595254
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000755763 049__ $$aISEA
000755763 050_4 $$aRC280.B7
000755763 08204 $$a616.99/480642$$223
000755763 24500 $$aRadiobiology of glioblastoma$$h[electronic resource] :$$brecent advances and related pathobiology /$$cLuigi Pirtoli, Giovanni Luca Gravina and Antonio Giordano, editors.
000755763 264_1 $$aSwitzerland :$$bHumana Press,$$c2016.
000755763 300__ $$a1 online resource.
000755763 336__ $$atext$$btxt$$2rdacontent
000755763 337__ $$acomputer$$bc$$2rdamedia
000755763 338__ $$aonline resource$$bcr$$2rdacarrier
000755763 4901_ $$aCurrent clinical pathology
000755763 504__ $$aIncludes bibliographical references.
000755763 5050_ $$aIntroduction and Background -- The "Radio-resistance" of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options -- Radiobiological Hints from Clinical Studies -- Chemo-radiotherapy: Radiation Total Dose and Fractionation -- Clinical Evidence and Radiobiological Background of Particle Radiation Therapy -- Mathematical Modeling of Radiobiological Parameters from Clinical Studies -- Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series -- Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond -- Basic Knowledge of Glioblastoma Radiobiology -- Molecular Radiobiology and Mathematical Modeling -- Genetic and Epigenetic Determinants in Tumor Initiation and Progression -- Tumor Microenvironment -- Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy -- mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models -- Glioma Stem-like Cells and Radiation Resistance -- Hypoxia and Radiation Resistance -- Invasiveness and Radiation Failures -- Nanoparticle Technology for Research Radiobiology -- The Molecular Classification of Glioblastoma as a Translational Instrument -- Translational Perspectives for Gene Therapy -- Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods -- From Molecular to Clinical Radiation Biology -- Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results -- Conclusive Remarks and Perspectives for Future Research.
000755763 506__ $$aAccess limited to authorized users.
000755763 520__ $$aThis text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators. .
000755763 588__ $$aOnline resource; title from PDF title page (viewed July 5, 2016).
000755763 650_0 $$aGlioblastoma multiforme$$xRadiotherapy.
000755763 650_0 $$aRadiobiology.
000755763 7001_ $$aPirtoli, Luigi,$$eeditor.
000755763 7001_ $$aGravina, Giovanni Luca,$$eeditor.
000755763 7001_ $$aGiordano, Antonio,$$eeditor.
000755763 77608 $$iPrint version:$$aPirtoli, Luigi$$tRadiobiology of Glioblastoma : Recent Advances and Related Pathobiology$$dCham : Springer International Publishing,c2016$$z9783319283036
000755763 830_0 $$aCurrent clinical pathology.
000755763 852__ $$bebk
000755763 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-28305-0$$zOnline Access$$91397441.1
000755763 909CO $$ooai:library.usi.edu:755763$$pGLOBAL_SET
000755763 980__ $$aEBOOK
000755763 980__ $$aBIB
000755763 982__ $$aEbook
000755763 983__ $$aOnline
000755763 994__ $$a92$$bISE