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Preface; Contents; About the Editor; Abbreviations; 1 Nanoscale Materials in Targeted Drug Delivery; Abstract; 1.1 Introduction; 1.2 Approaches for Synthesis of Nanoscale Materials; 1.3 Characterisation of Nanoscale Materials; 1.4 Types of Nanoscale Materials; 1.5 Targeted Drug Delivery; 1.6 Various Nanoscale Materials in Drug Delivery; 1.6.1 Polymeric Nanoparticles; 1.6.2 Metallic Nanoparticles; 1.6.3 Liposomes; 1.6.4 Quantum Dots; 1.6.5 Polymeric Micelles; 1.6.6 Carbon Nanotubes; 1.6.7 Dendrimers; 1.6.8 Magnetic Nanoparticles; 1.7 Conclusions; Acknowledgments
2 Biodegradable Nanoparticles and Their In Vivo FateAbstract; 2.1 Introduction; 2.2 Synthesis of Biodegradable Nanoparticles; 2.2.1 Synthesis of PLGA and PLA Nanoparticles; 2.2.2 Synthesis of Chitosan Nanoparticles; 2.2.3 Synthesis of Protein Nanoparticles; 2.3 Biodegradable Nanoparticles for Drug Delivery; 2.3.1 Biodegradable Nanoparticles for Delivery of Anticancer Drugs; 2.3.2 Biodegradable Nanoparticles for Delivery of Psychotic Drugs; 2.3.3 Biodegradable Nanoparticles for Delivery of Antimicrobial Drugs; 2.3.4 Biodegradable Nanoparticles for Delivery of Hepatoprotective Drugs
2.3.5 Biodegradable Nanoparticles for Proteins, Peptides and Nucleic Acids Delivery2.4 Drug Release Mechanisms from Biodegradable Nanoparticles; 2.5 Targeted Drug Delivery Using Biodegradable Nanoparticles; 2.6 Biological Barriers Encountered by Biodegradable NPs; 2.7 In Vivo Fate of Biodegradable Nanoparticles; 2.8 Toxicity of Biodegradable Nanoparticles; 2.9 Conclusions; Acknowledgments; References; 3 Metallic Nanoparticles, Toxicity Issues and Applications in Medicine; Abstract; 3.1 Introduction; 3.2 Physico-Chemical Properties of Metal and Metal Oxide NPs
3.3 Synthesis of Metal and Metal Oxide NPs3.3.1 Electrochemical Synthesis; 3.3.2 Sonochemical Method; 3.3.3 Thermal Decomposition; 3.3.4 Laser Ablation; 3.3.5 Chemical Reduction; 3.3.6 Polyol Method; 3.3.7 Microemulsion; 3.3.8 Biological Synthesis; 3.3.8.1 Bacteria-Mediated Synthesis; 3.3.8.2 Fungus-Mediated Synthesis; 3.3.8.3 Actinomycetes- and Yeast-Mediated Synthesis; 3.3.8.4 Plant-Mediated Synthesis; 3.4 Effect of Shape, Size and Surface Chemistry of NPs on Their Properties and Biological Behaviour; 3.5 Medical Prospects of Metallic Nanoparticles; 3.5.1 Disease Diagnostics
3.5.1.1 Imaging3.5.1.2 Cancer Detection; 3.5.2 Disease Therapy; 3.5.2.1 Anti-microbial Activity; 3.5.2.2 Cancer Treatment; 3.5.2.3 Treatment of Other Diseases; 3.5.2.4 Radiotherapy; 3.5.2.5 Gene Therapy; 3.5.2.6 Targeted Delivery and Controlled Drug Release; 3.5.3 Tissue Engineering; 3.5.4 Wound Healing and Skin Repair; 3.5.5 Theranostics; 3.6 Toxicity Issues Related to the Use of Nanomaterials; 3.7 Conclusions; Acknowledgements; References; 4 Liposomal and Phytosomal Formulations; Abstract; 4.1 Introduction; 4.2 Types of Liposomes; 4.2.1 Liposomes Based on Drug Delivery Systems
2 Biodegradable Nanoparticles and Their In Vivo FateAbstract; 2.1 Introduction; 2.2 Synthesis of Biodegradable Nanoparticles; 2.2.1 Synthesis of PLGA and PLA Nanoparticles; 2.2.2 Synthesis of Chitosan Nanoparticles; 2.2.3 Synthesis of Protein Nanoparticles; 2.3 Biodegradable Nanoparticles for Drug Delivery; 2.3.1 Biodegradable Nanoparticles for Delivery of Anticancer Drugs; 2.3.2 Biodegradable Nanoparticles for Delivery of Psychotic Drugs; 2.3.3 Biodegradable Nanoparticles for Delivery of Antimicrobial Drugs; 2.3.4 Biodegradable Nanoparticles for Delivery of Hepatoprotective Drugs
2.3.5 Biodegradable Nanoparticles for Proteins, Peptides and Nucleic Acids Delivery2.4 Drug Release Mechanisms from Biodegradable Nanoparticles; 2.5 Targeted Drug Delivery Using Biodegradable Nanoparticles; 2.6 Biological Barriers Encountered by Biodegradable NPs; 2.7 In Vivo Fate of Biodegradable Nanoparticles; 2.8 Toxicity of Biodegradable Nanoparticles; 2.9 Conclusions; Acknowledgments; References; 3 Metallic Nanoparticles, Toxicity Issues and Applications in Medicine; Abstract; 3.1 Introduction; 3.2 Physico-Chemical Properties of Metal and Metal Oxide NPs
3.3 Synthesis of Metal and Metal Oxide NPs3.3.1 Electrochemical Synthesis; 3.3.2 Sonochemical Method; 3.3.3 Thermal Decomposition; 3.3.4 Laser Ablation; 3.3.5 Chemical Reduction; 3.3.6 Polyol Method; 3.3.7 Microemulsion; 3.3.8 Biological Synthesis; 3.3.8.1 Bacteria-Mediated Synthesis; 3.3.8.2 Fungus-Mediated Synthesis; 3.3.8.3 Actinomycetes- and Yeast-Mediated Synthesis; 3.3.8.4 Plant-Mediated Synthesis; 3.4 Effect of Shape, Size and Surface Chemistry of NPs on Their Properties and Biological Behaviour; 3.5 Medical Prospects of Metallic Nanoparticles; 3.5.1 Disease Diagnostics
3.5.1.1 Imaging3.5.1.2 Cancer Detection; 3.5.2 Disease Therapy; 3.5.2.1 Anti-microbial Activity; 3.5.2.2 Cancer Treatment; 3.5.2.3 Treatment of Other Diseases; 3.5.2.4 Radiotherapy; 3.5.2.5 Gene Therapy; 3.5.2.6 Targeted Delivery and Controlled Drug Release; 3.5.3 Tissue Engineering; 3.5.4 Wound Healing and Skin Repair; 3.5.5 Theranostics; 3.6 Toxicity Issues Related to the Use of Nanomaterials; 3.7 Conclusions; Acknowledgements; References; 4 Liposomal and Phytosomal Formulations; Abstract; 4.1 Introduction; 4.2 Types of Liposomes; 4.2.1 Liposomes Based on Drug Delivery Systems