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Table of Contents
Part 1. General Principles
Physiology of Hemostasis
Laboratory Assessment of Physiologic and Pathologic Hemostasis
Current Anticoagulation Drugs and Mechanisms of Action
Reversal of Target-Specific Oral Anticoagulants
Overview, Treatment, Measurement, and Modification of Platelet Function
Role of Antiplatelet Therapy in Neurosurgery: Efficacy and Safety Profiles
Part 2. Coagulation Issues Across all Patient Spectrums
Congenital Coagulation Disorders
Acquired Coagulation Disorders
Regulation and Dysregulation of Fibrinolysis
Risks Associated with Administration of Allogeneic Blood Components
Common Coagulation Disorders That May Arise Intraoperatively
Evaluation and Management of Untoward Intraoperative Bleeding
Treatment of Disseminated Intravascular Coagulation (DIC)
Heparin-Induced Thrombocytopenia (HIT)
Anticoagulation in Cardiovascular Diseases
Workup and Treatment of Pulmonary Embolus
Part 3. Coagulation Issues Specific to Neurosurgery
Classes of Drugs and Blood Products for Acute Reversal of Anticoagulant Effect
Rescue Strategies to Facilitate Emergency Neurosurgery in Patients on Antiplatelet or Anticoagulant Agents
Considerations for Coagulation in the Multi-Trauma Patient
Cerebral Venous Sinus Thrombosis
Coagulation Studies in Preoperative Neurosurgery Patients
Safe Strategies for Gradual Suspension and Re-institution of Anticoagulation to Permit Elective Surgery
Spontaneous Intracerebral Hemorrhage due to Coagulation Disorders
Prophylactic Screening for Venous Thromboembolism in Neurosurgical Patients
Venous Thromboembolism Prophylaxis in Neurosurgery
Can Patients with Known Intracranial and Intraspinal Vascular Lesions be Anticoagulated?
Intrathecal Access and Devices in Patients on Antiplatelet or Anticoagulant Therapy
Is it Safe to Shunt Anti-coagulated NPH Patients?
Surgical Hemostasis in the Era of Anticoagulation: Guidelines and Recommendations Summary.
Physiology of Hemostasis
Laboratory Assessment of Physiologic and Pathologic Hemostasis
Current Anticoagulation Drugs and Mechanisms of Action
Reversal of Target-Specific Oral Anticoagulants
Overview, Treatment, Measurement, and Modification of Platelet Function
Role of Antiplatelet Therapy in Neurosurgery: Efficacy and Safety Profiles
Part 2. Coagulation Issues Across all Patient Spectrums
Congenital Coagulation Disorders
Acquired Coagulation Disorders
Regulation and Dysregulation of Fibrinolysis
Risks Associated with Administration of Allogeneic Blood Components
Common Coagulation Disorders That May Arise Intraoperatively
Evaluation and Management of Untoward Intraoperative Bleeding
Treatment of Disseminated Intravascular Coagulation (DIC)
Heparin-Induced Thrombocytopenia (HIT)
Anticoagulation in Cardiovascular Diseases
Workup and Treatment of Pulmonary Embolus
Part 3. Coagulation Issues Specific to Neurosurgery
Classes of Drugs and Blood Products for Acute Reversal of Anticoagulant Effect
Rescue Strategies to Facilitate Emergency Neurosurgery in Patients on Antiplatelet or Anticoagulant Agents
Considerations for Coagulation in the Multi-Trauma Patient
Cerebral Venous Sinus Thrombosis
Coagulation Studies in Preoperative Neurosurgery Patients
Safe Strategies for Gradual Suspension and Re-institution of Anticoagulation to Permit Elective Surgery
Spontaneous Intracerebral Hemorrhage due to Coagulation Disorders
Prophylactic Screening for Venous Thromboembolism in Neurosurgical Patients
Venous Thromboembolism Prophylaxis in Neurosurgery
Can Patients with Known Intracranial and Intraspinal Vascular Lesions be Anticoagulated?
Intrathecal Access and Devices in Patients on Antiplatelet or Anticoagulant Therapy
Is it Safe to Shunt Anti-coagulated NPH Patients?
Surgical Hemostasis in the Era of Anticoagulation: Guidelines and Recommendations Summary.