@article{755827,
      recid = {755827},
      author = {Watanabe, Takeshi, and Takahama, Yousuke,},
      title = {Synthetic immunology [electronic resource] /},
      pages = {1 online resource (xi, 200 pages) :},
      abstract = {This book reviews the emerging studies of synthetic  immunology, including the development and regeneration of  immune cells, immune organ development and artificial  regeneration, and the synthetic approach towards  understanding human immune system. Immunology has developed  rapidly over the last 50 years through the incorporation of  new methods and concepts in cell and molecular biology,  genetics, genomics and proteomics. This progress is the  result of works by many excellent researchers all over the  world. Currently, immunological research has accumulated  detailed knowledge on basic mechanisms of immunity and is  in the process to change medical practices. Yet, due to the  enormous complexity of the immune system, many aspects on  the regulation and function of this system remain unknown.  Synthetic biology uses gain-of-function rather than  loss-of-function approaches. The goals of synthetic biology  can be described in a simple phrase "rebuild, alter, and  understand," namely, to rebuild minimal functional systems  using well-defined parts from nature and then to perturb  the system to understand its working principles. Given the  richness of accumulated knowledge in molecular and cellular  mechanisms of the immune system, we now begin adapting the  concepts of synthetic biology to immunology. An immune  response is a spatiotemporal phenomenon occurring at a  given time and at a specialized place in the body. One goal  of synthetic immunology is to reconstruct artificial  microenvironments for better understanding of an immune  response. We hope this yet-to-be-experimental approach of  synthetic immunology and the compilation of this book will  aid our further understanding of the immune system and  future devising the tools to manipulate the immune system  for therapy and prevention of the diseases.},
      url = {http://library.usi.edu/record/755827},
}