000755827 000__ 03991cam\a2200433Ii\4500
000755827 001__ 755827
000755827 005__ 20230306141815.0
000755827 006__ m\\\\\o\\d\\\\\\\\
000755827 007__ cr\cn\nnnunnun
000755827 008__ 160613s2016\\\\ja\a\\\\o\\\\\000\0\eng\d
000755827 020__ $$a9784431560272$$q(electronic book)
000755827 020__ $$a4431560270$$q(electronic book)
000755827 020__ $$z9784431560258
000755827 035__ $$aSP(OCoLC)ocn951623770
000755827 035__ $$aSP(OCoLC)951623770
000755827 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dYDXCP$$dGW5XE$$dIDEBK$$dEBLCP$$dAZU$$dOCLCF$$dN$T$$dCOO
000755827 049__ $$aISEA
000755827 050_4 $$aQR186
000755827 08204 $$a571.9/646$$223
000755827 24500 $$aSynthetic immunology$$h[electronic resource] /$$cTakeshi Watanabe, Yousuke Takahama, editors
000755827 264_1 $$aJapan :$$bSpringer,$$c2016.
000755827 300__ $$a1 online resource (xi, 200 pages) :$$billustrations.
000755827 336__ $$atext$$btxt$$2rdacontent
000755827 337__ $$acomputer$$bc$$2rdamedia
000755827 338__ $$aonline resource$$bcr$$2rdacarrier
000755827 504__ $$aIncludes bibliographical references.
000755827 5050_ $$a1. Overview (Michael Reth) -- 2. Development and regeneration of HSCs (Hiromitsu Nakauchi) -- 3. Development and regeneration of T cells (Hiroshi Kawamoto) -- 4. Controlling the thymus development (Richard Boyd) -- 5. Artificial thymus microenvironment (JC Zuniga-Pflucker) -- 6. Controlling lymph node development (Sergio Lira) -- 7. Artificial lymph nodes (Takeshi Watanabe) -- 8. Lymph nodes as surrogate organ (Eric Lagasse) -- 9. Tissue reconstitution by 3D bio-printer (Makoto Nakamura) -- 10. Reconstitution of human immune system in the mouse (Fumihiko Ishikawa).
000755827 506__ $$aAccess limited to authorized users.
000755827 520__ $$aThis book reviews the emerging studies of synthetic immunology, including the development and regeneration of immune cells, immune organ development and artificial regeneration, and the synthetic approach towards understanding human immune system. Immunology has developed rapidly over the last 50 years through the incorporation of new methods and concepts in cell and molecular biology, genetics, genomics and proteomics. This progress is the result of works by many excellent researchers all over the world. Currently, immunological research has accumulated detailed knowledge on basic mechanisms of immunity and is in the process to change medical practices. Yet, due to the enormous complexity of the immune system, many aspects on the regulation and function of this system remain unknown. Synthetic biology uses gain-of-function rather than loss-of-function approaches. The goals of synthetic biology can be described in a simple phrase "rebuild, alter, and understand," namely, to rebuild minimal functional systems using well-defined parts from nature and then to perturb the system to understand its working principles. Given the richness of accumulated knowledge in molecular and cellular mechanisms of the immune system, we now begin adapting the concepts of synthetic biology to immunology. An immune response is a spatiotemporal phenomenon occurring at a given time and at a specialized place in the body. One goal of synthetic immunology is to reconstruct artificial microenvironments for better understanding of an immune response. We hope this yet-to-be-experimental approach of synthetic immunology and the compilation of this book will aid our further understanding of the immune system and future devising the tools to manipulate the immune system for therapy and prevention of the diseases.
000755827 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed June 17, 2016).
000755827 650_0 $$aImmune response.
000755827 650_0 $$aImmunotechnology.
000755827 7001_ $$aWatanabe, Takeshi,$$d1940-$$eeditor.
000755827 7001_ $$aTakahama, Yousuke,$$eeditor.
000755827 77608 $$iPrint version:$$tSynthetic immunology.$$d[Tokyo], Japan : Springer, c2016$$z9784431560258$$w(DLC)  2016939272
000755827 852__ $$bebk
000755827 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-4-431-56027-2$$zOnline Access$$91397441.1
000755827 909CO $$ooai:library.usi.edu:755827$$pGLOBAL_SET
000755827 980__ $$aEBOOK
000755827 980__ $$aBIB
000755827 982__ $$aEbook
000755827 983__ $$aOnline
000755827 994__ $$a92$$bISE