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Title
PI3K-mTOR in cancer and cancer therapy [electronic resource] / Nandini Dey, Pradip De, Brian Leyland-Jones, editors.
ISBN
9783319342115 (electronic book)
3319342118 (electronic book)
9783319342092
Published
New York : Humana Press, 2016.
Language
English
Description
1 online resource (xxiv, 294 pages) : color illustrations.
Call Number
RC268.4
Dewey Decimal Classification
616.99/4
Summary
In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway's involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.
Note
Includes index.
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed June 20, 2016).
Series
Cancer drug discovery and development.
PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics
Part 1: PI3K-mTOR Pathway in Cancers
The mTOR Complexes in Cancer Cell Metabolism
PI3K-AKT-mTOR Pathway Co-operates with the DNA Damage Repair Pathway: Carcinogenesis in Triple Negative Breast Cancers and Beyond
The AKT-mTOR Signaling Pathway for Drug Response Prediction and Prognostic Signatures
Resistance to PI3K Pathway Inhibition
Part 2: PI3K-mTOR Pathway in Cancer Medicine
Combination Therapies Targeting the PI3K/AKT/mTOR Pathways
Phospho-Inositol-3-Kinase Activity and Dysregulation in Pediatric Leukemia and Lymphoma
HER2 Signaling Network in Advanced Breast Cancer: Opportunities for Combination Therapies
The PI3K-mTOR Pathway in Prostate Cancer: Biological Significance and Therapeutic Opportunities.
