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000756332 020__ $$a9783319296357$$q(electronic book)
000756332 020__ $$a3319296353$$q(electronic book)
000756332 020__ $$z9783319296333
000756332 035__ $$aSP(OCoLC)ocn953455862
000756332 035__ $$aSP(OCoLC)953455862
000756332 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dYDXCP$$dIDEBK$$dEBLCP$$dGW5XE$$dN$T$$dAZU
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000756332 08204 $$a571.6/4$$223
000756332 24500 $$aVascular ion channels in physiology and disease$$h[electronic resource] /$$cIrena Levitan, Alex M. Dopico, editors ; foreword by Mark T. Nelson.
000756332 264_1 $$aSwitzerland :$$bSpringer,$$c2016.
000756332 300__ $$a1 online resource (xvii, 431 pages) :$$billustrations.
000756332 336__ $$atext$$btxt$$2rdacontent
000756332 337__ $$acomputer$$bc$$2rdamedia
000756332 338__ $$aonline resource$$bcr$$2rdacarrier
000756332 500__ $$aIncludes index.
000756332 5050_ $$aForeword -- Endothelial cell ion channel expression and function in arterioles and resistance arteries -- Contribution and Regulation of Calcium channels in Endothelial Cells -- Mitochondrial depolarization in endothelial and other vascular cells and their role in the regulation of cerebral vascular tone -- Ion channels in Hypertension and Control of Blood Flow: Electrical conduction along endothelium of resistance arteries -- Ca2+/calmodulin-gated small- and intermediate-conductance KCa channels in cardiovascular regulation: Targets for novel pharmacological treatments -- Regional Variation in Arterial Myogenic Responsiveness -- Links to Potassium Channel Diversity/Function -- Ion Channel Trafficking and Control of Arterial Contractility -- Abnormalities of Vascular Ion Channels during Hypertension -- Kv7 Potassium Channels as Therapeutic Targets in Cerebral Vasospasm -- Lysosomal Transient Receptor Potential Mucolipin (TRPML) Channels in Vascular Regulation and Diseases -- Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth Muscle -- Role of mechanosensitive TRP channels in Abnormal Vasculature of Tumors -- TRPC and Orai channels in store-operated calcium entry and vascular remodeling -- Smooth muscle cell ion channels in pulmonary arterial hypertension: pathogenic role in pulmonary vasoconstriction and vascular remodeling -- Physiological roles and cholesterol sensitivity of endothelial inwardly-rectifying K+ channels: specific cholesterol-protein interactions through non annular binding sites -- Membrane lipids and regulation of smooth muscle ion channels -- Transient receptor potential channels in metabolic syndrome-induced coronary artery disease -- Mitochondrial ion channels in metabolic disease -- Index.
000756332 506__ $$aAccess limited to authorized users.
000756332 520__ $$aIon channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.
000756332 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed July 18, 2016).
000756332 650_0 $$aIon channels.
000756332 650_0 $$aBlood-vessels$$xDiseases$$xMolecular aspects.
000756332 7001_ $$aLevitan, Irena,$$eeditor.
000756332 7001_ $$aDopico, Alex M.,$$eeditor.
000756332 852__ $$bebk
000756332 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-29635-7$$zOnline Access$$91397441.1
000756332 909CO $$ooai:library.usi.edu:756332$$pGLOBAL_SET
000756332 980__ $$aEBOOK
000756332 980__ $$aBIB
000756332 982__ $$aEbook
000756332 983__ $$aOnline
000756332 994__ $$a92$$bISE