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000759841 020__ $$a9784431560241$$q(electronic book)
000759841 020__ $$a4431560246$$q(electronic book)
000759841 020__ $$z9784431560227
000759841 0247_ $$a10.1007/978-4-431-56024-1$$2doi
000759841 035__ $$aSP(OCoLC)ocn954054898
000759841 035__ $$aSP(OCoLC)954054898
000759841 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dYDXCP$$dIDEBK$$dGW5XE$$dEBLCP$$dAZU$$dCOO$$dOCLCF
000759841 049__ $$aISEA
000759841 050_4 $$aRB131
000759841 08204 $$a616/.0473$$223
000759841 1001_ $$aMaru, Yoshiro,$$eauthor.
000759841 24510 $$aInflammation and metastasis$$h[electronic resource] /$$cYoshiro Maru.
000759841 264_1 $$aJapan :$$bSpringer,$$c2016.
000759841 300__ $$a1 online resource (xx, 505 pages) :$$billustrations.
000759841 336__ $$atext$$btxt$$2rdacontent
000759841 337__ $$acomputer$$bc$$2rdamedia
000759841 338__ $$aonline resource$$bcr$$2rdacarrier
000759841 504__ $$aIncldues bibliographical references and index.
000759841 5050_ $$aPART I WHAT IS INFLAMMATION -- 1 General thinking -- 2 Leukocytes -- 3 Triangle -- 4 Sterile inflammation -- PART II WHAT IS ENDOGENOUS LIGAND -- 5 Self and non-self -- 6 Field extension -- 7 Endogenous TLR4 ligands -- 8 Auto-inflammatory disorders -- PART III CANCER -- 9 Cancer in general -- 10 Basic research -- 11 Tumor microenvironment -- 12 Whole-body matter -- PART IV HOMEOSTATIC INFLAMMATION AND METASTASIS -- 13 Pre-metastasis -- 14 What is homeostasis -- 15 Explanation of metastasis -- 16 Therapeutic potential.
000759841 506__ $$aAccess limited to authorized users.
000759841 520__ $$aThis book provides the latest information on cancer metastasis from the standpoint of inflammation, especially innate immune reactions caused by endogenous mediators but not exogenous pathogens, with ideas on how to understand the complicated mechanisms of metastasis as well as to interpret therapeutic targets. The book includes the topic of the emerging roles of endogenous TLR4 ligands whose functions are shared intriguingly by metastasis and auto-inflammatory diseases such as rheumatoid arthritis. For example, most cancer therapies established so far are effective initially. However, they eventually face the great obstacles of drug resistance, immune evasion, and metastatic progression. One of the endogenous TLR4 ligands is thought to contribute to all three processes. The most important features of the book are to explain a concept of homeostatic inflammation, disturbance of which in the lungs gives rise to the establishment of a pre-metastatic pulmonary microenvironment based on primary tumor-mediated hijacking of the innate immune defense system against respiratory infection. In addition, structure-based thinking is another important feature of this book. It is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, in the center of which cancer is located. Given the proposal of precision medicine by President Obama in the United States in 2015 and the recent success of immune-modulator-based therapy, this book will appeal to researchers in a variety of fields with the title of the book connecting the worst disease (metastasis) and the most fundamental event (inflammation) that is common to many diseases.
000759841 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed August 5, 2016).
000759841 650_0 $$aInflammation.
000759841 650_0 $$aMetastasis.
000759841 650_0 $$aCancer$$xMolecular aspects.
000759841 650_0 $$aCancer$$xImmunological aspects.
000759841 77608 $$iPrint version:$$z9784431560227
000759841 852__ $$bebk
000759841 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-4-431-56024-1$$zOnline Access$$91397441.1
000759841 909CO $$ooai:library.usi.edu:759841$$pGLOBAL_SET
000759841 980__ $$aEBOOK
000759841 980__ $$aBIB
000759841 982__ $$aEbook
000759841 983__ $$aOnline
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