Preface; Contents; Part I: Basic Biology and Anatomy; 1: Tendon Structure and Composition; Introduction; Collagens; Proteoglycans; Glycoproteins and Other Molecules; Cells; Bone Insertion; Myotendinous Junction; Variations in Tendon Composition According to Tendon Function; Variation in Tendon Collagen; Variation in Non-collagenous Components; Conclusions; References; 2: Collagen Homeostasis and Metabolism; Introduction; Tendon Composition; Tendon Metabolism; Collagen Synthesis and Turnover; Force Transmission Within the Tendon; Chronic Loading of Tendon
Physical Training

Unloading of TendonThe Aging Tendon; Tendon Connections with Bone and Skeletal Muscle; Conclusion; References; 3: Blood Supply; Introduction; Measurement of Blood Circulation of Human Tendon Using Red Laser Lights; Effect of Heating on Blood Circulation of Human Tendon; Effect of Acupuncture on Blood Circulation of Human Tendon; Conclusion; References; 4: Tendon Innervation; Introduction; Innervation of Tendons; Neuromediators in Healthy Tendon; Sensory Neuromediators; Autonomic Neuromediators; Excitatory Neuromediators; Nerve Ingrowth After Tendon Injury; Inflammatory Healing Phase

Proliferative Healing PhaseRemodeling Healing Phase; Protracted Nerve Ingrowth in Tendinopathy; Sensory Neuromediators; Autonomic Neuromediators; Excitatory Neuromediators; Effect of Hampered Neuronal Supply; Sensory Neuromediators; Autonomic Neuromediators; Observations in Diabetes Mellitus; Neuronal Effects of Tendon Loading; Conclusion; References; 5: Tendon Stem Cells: Mechanobiology and Development of Tendinopathy; Introduction; Discovery of TSCs; A Mechanical Loading System to Study TSC Mechanobiology In Vitro; Use of Mouse Treadmill Running to Study of Mechanobiology of Tendon In Vivo

The Role of TSCs in the Development of TendinopathyMechanobiological Response of TSCs In Vitro; The Mechanobioological Responses of TSCs In Vivo; Concluding Remarks; References; 6: Informing Stem Cell-Based Tendon Tissue Engineering Approaches with Embryonic Tendon Development; Introduction; Embryonic Tendon Mechanical Properties Elaborate During Development; Embryonic Tendon Elastic Modulus Is Dependent on the Developmental Stage; Tensile Testing Measures the Bulk Mechanical Properties of Embryonic Tendon

Atomic Force Microscopy (AFM) Measures Cell Length-Scale Embryonic Tendon Mechanical PropertiesECM Content Changes During Embryonic Development But Does Not Correlate Directly with Mechanical Properties; Lysyl Oxidase (LOX)-Mediated Collagen Crosslink Density Contributes to the Mechanical Properties of Embryonic Tendon; LOX-Mediated Collagen Crosslinks Are Potential Markers of Tendon Development; The Actin Cytoskeleton Contributes to Embryonic Tendon Mechanical Properties and Is a Biomarker of Development; Embryonic Tendon Development May be Influenced by Muscle-Generated Mechanical Loading