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000760171 019__ $$a957464822$$a957607342
000760171 020__ $$a9783319431574$$q(electronic book)
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000760171 24500 $$aSkin stress response pathways$$h[electronic resource] :$$benvironmental factors and molecular opportunities /$$cGeorg T. Wondrak, editor.
000760171 260__ $$aCham :$$bSpringer,$$c2016.
000760171 300__ $$a1 online resource (454 pages)
000760171 336__ $$atext$$btxt$$2rdacontent
000760171 337__ $$acomputer$$bc$$2rdamedia
000760171 338__ $$aonline resource$$bcr$$2rdacarrier
000760171 500__ $$a2.4.3 Mimicking, In Vitro and/or Ex Vivo, the Impact of Some Environmental Factors upon Squalene Oxidization
000760171 5050_ $$aPreface; Contents; 1 The Skin Lipidome Under Environmental Stress-Technological Platforms, Molecular Pathways and Translational Opportunities; Abstract; 1.1 Introduction; 1.1.1 Lipids of the Skin-Distribution of Stress Accessible Lipid Classes ; 1.2 Lipidomic Methods to Analyze One or More Lipid Classes; 1.2.1 Fatty Acyls (Fatty Acids, Eicosanoids, Endocannabinoids); 1.2.2 Glycerolipids (Tri- and, Di-Acylglycerols); 1.2.3 Glycerophospholipids (PC, PE, PI, PS, PG, PA, Cardiolipin) ; 1.2.4 Sphingolipids (Sphingomyelin, Sulfatides, Sphingosine, Ceramides, Gangliosides); 1.2.5 Sterol Lipids
000760171 5058_ $$a1.2.6 Prenol Lipids1.2.7 Methods for Several Lipid Classes; 1.2.8 Lipid Organization; 1.2.9 Lipid Imaging; 1.3 How Stressors Affect the Lipidome; 1.3.1 Stress Induced Enzymatic Pathways that Affect the Lipidome; 1.3.1.1 Phospholipase A2 (PLA2) and Other Phospholipases; 1.3.1.2 Cyclooxygenases and Prostaglandin Synthases; 1.3.1.3 Lipoxygenases; 1.3.1.4 Peroxiredoxins; 1.3.1.5 PAF Acetyltransferase and PAF Hydrolase; 1.3.1.6 Other UV/Chemical Stress Regulated Lipid Metabolizing Enzymes; 1.3.2 Non-enzymatic Pathways that Affect the Skin Lipidome
000760171 5058_ $$a1.4 Stress Generated Lipid Modifications and Bioactive Lipid Mediators1.4.1 Fatty Acyls Derived Bioactive Lipids; 1.4.1.1 EICOSANOIDS; 1.4.1.2 Endocannabinoids; 1.4.2 Glycerolipids (Tri-, Di-Acylglycerols) ; 1.4.3 Glycerophospholipids Derived Bioactive Mediators; 1.4.3.1 Phosphatidylethanolamines; 1.4.3.2 Phosphatidylcholines; 1.4.3.3 PAF-Like Lipids; 1.4.4 Sphingolipid Changes; 1.4.4.1 Ceramides; 1.4.4.2 Glycosphingolipids; 1.4.5 Bioactive Sterol Lipids; 1.4.6 Bioactive Prenol Lipids; 1.5 Translational Applications and Therapeutic Opportunities of Lipidomics
000760171 5058_ $$a1.5.1 Drug Development Opportunities1.5.2 Mechanistic Insights into Disease from Lipidomics; 1.5.3 Cosmetic Applications; 1.5.4 Lipidomics for Biomarker Discovery ; References; 2 Squalene and Skin Barrier Function: From Molecular Target to Biomarker of Environmental Exposure; Abstract; 2.1 Introduction: The Human Skin, a Constantly Adaptive Organ; 2.1.1 Age-Related Changes; 2.1.2 Environment Exposure Changes; 2.2 Specificities of the Stratum Corneum; 2.2.1 A Cornified Protecting Barrier Covered by Sebum; 2.2.2 The Human Sebum; 2.2.2.1 Quantitative Aspects; 2.2.2.2 Qualitative Aspects
000760171 5058_ $$a2.3 Squalene (SQ), a Key Element2.3.1 A Biological Human Curiosity; 2.3.2 Structure/Properties of SQ ; 2.3.3 Squalene, a Strong Acceptor of All Forms of Oxygen; 2.3.4 Squalene and the Resident Oxidative Skin Microflora; 2.3.5 Squalene Facing Singlet Oxygen Released by Porphyrins; 2.3.5.1 Effect of Some Anti-oxidants; 2.3.5.2 SQOOH Properties ; 2.4 Squalene as a Reliable Bio-marker of an Oxidative Environment; 2.4.1 In Real Life (In Vivo) Conditions; 2.4.2 Possible Influences of Other Factors from a Polluted Aerial Environment
000760171 506__ $$aAccess limited to authorized users.
000760171 520__ $$aIt is now established that the interplay between environmental exposure and molecular stress response pathways plays a critical role in skin health and disease, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit patients in the near future. Coauthored by recognized international leaders in molecular and clinical biomedical sciences, this novel book provides a comprehensive perspective on environmental exposure-induced skin stress response pathways. Focusing on molecular opportunities targeting skin stress response pathways that are involved in cutaneous barrier function and repair, antimicrobial defense, immune regulation, inflammation, and malignant progression, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in skin health and disease with implications for small molecule therapeutic development.
000760171 588__ $$aDescription based on print version record.
000760171 650_0 $$aSkin$$xDiseases$$xMolecular aspects.
000760171 650_0 $$aSkin$$xInflammation.
000760171 7001_ $$aWondrak, Georg T.
000760171 77608 $$iPrint version:$$aWondrak, Georg T.$$tSkin Stress Response Pathways : Environmental Factors and Molecular Opportunities$$dCham : Springer International Publishing,c2016$$z9783319431550
000760171 852__ $$bebk
000760171 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-43157-4$$zOnline Access$$91397441.1
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000760171 980__ $$aEBOOK
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000760171 982__ $$aEbook
000760171 983__ $$aOnline
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