Preface; Acknowledgments; Contents; Contributors; Abbreviations; Part I: Pharmacology and Mechanisms; 1: Chemistry, Pharmacodynamics, and Pharmacokinetics of NSAIDs; Introduction; Chemistry; Pharmacodynamics; Nonselective vs. Isoform-Specific COX Inhibitors; Structural Factors; Kinetic Factors; Allosteric Factors; COX-Independent Actions; Pharmacokinetics; Absorption; Distribution; Elimination; References; 2: Principles, Mechanisms of Action, and Future Prospects of Anti-inflammatory Drugs; Introduction; Eicosanoids; COX Pathway; COX-2; COX Inhibitors; Selective COX-2 Inhibitors (COXIBs)

MPGES-1 InhibitorsAgonists and Antagonists of Prostanoid Receptors; Cyclopentenone PGs; Other Approaches; Drugs Acting on the 5-LOX Pathway; Dual COX-2/5-LO Inhibitors; NSAIDs Releasing Nitric Oxide (NO) or Hydrogen Sulfide (H2S); Aspirin-Triggered 15-Epi-lipoxins; Conclusions; References; Part II: Clinical Effects and Drug Safety; 3: Efficacy of NSAIDs in the Treatment of Rheumatic Diseases; Introduction; Osteoarthritis; Rheumatoid Arthritis; Ankylosing Spondylitis; Acute Gout; Conclusion; References

4: Adverse Effects of NSAIDs in the Gastrointestinal Tract: Risk Factors of Gastrointestinal Toxicity with NSAIDsIntroduction; Epidemiology; Pathogenesis; Gastrointestinal Toxicity of NSAIDS; Upper Gastrointestinal Tract; Lower Gastrointestinal Tract; Other Gastrointestinal Symptoms; Risk Factors for Gastrointestinal Toxicity; Concomitant Use of Aspirin and Another NSAID; Concomitant Use with Anticoagulants; Concomitant Use with Corticosteroids; Helicobacter pylori Infection; Past History of Complicated Ulcers; Stratification by Gastrointestinal Risks

Strategies to Reduce NSAID-Associated UlcersHistamine-2 Receptor Antagonist; Misoprostol; Proton-Pump Inhibitors; COX-2 Inhibitors; Cardiovascular Risks of NSAIDS; Balancing Cardiovascular and Gastrointestinal Risks; Conclusions; References; 5: Adverse Effects of Nonsteroidal Anti-inflammatory Drugs on the Cardiovascular System; The Need for NSAID Therapy in Patients with Cardiovascular Disease; Cardiovascular Adverse Effects of NSAIDs; Myocardial Infarction; Randomized Trials and Meta-analyses Focused on Cardiovascular Events; Meta-analyses; Time Dependence of NSAID-Associated CV Risk

CV Risk of NSAID Use After First-Time Myocardial InfarctionCV Risk of NSAIDs in Special Patient Populations; Inflammatory Arthritides; Osteoarthritis; Diabetes Mellitus; CV Adverse Effects of NSAIDs: Is There a Genetic Predisposition?; CV Adverse Effects of NSAIDs: Is COX-2-Mediated Immunomodulation Responsible?; Stroke; Non-ischemic CV Adverse Effects of NSAIDs; Congestive Heart Failure; Atrial Fibrillation; Effects on Renal Function and Blood Pressure; NSAID-Induced Fluid and Electrolyte Disturbances; Peripheral Edema