Part I. Basic Pharmacologic Principles
1. Pharmacokinetics and Pharmacodynamics of Anesthetics
2. A Review of Mechanisms of Inhalational Anesthetic Agents
3. Pharmacokinetics, pharmacodynamics and physical properties of Inhalational agents
4. Principles of Total Intravenous Anesthesia
5. Perioperative Considerations in Pharmacology
Part II. Drug Classes
6. Anesthetic Induction Agents
7. Analgesics: Opiate agonists, mixed agonist/antagonists and antagonists for acute pain management
8. Analgesics: Opioids for chronic pain management and surgical considerations
9. Nonopioid Analgesic and Adjunct Drugs
10. Benzodiazepines and muscle relaxants
11. Pharmacology of Local Anesthetics
12. Neuromuscular Blockers
13. Reversal agents
14. Drugs acting on the autonomic nervous system
15. Antihypertensives, diuretics and antidysrhythmics
16. Peripheral vasodilators
17. Nitric oxide and Pulmonary Vasodilators
18. Asthma and COPD agents
19. Hormones, Part 1: Thyroid and Corticosteroid Hormones
20. Hormones, Part 2: Insulin and Other glucose controlling Medications
21. Antacids, Gastrointestinal Prokinetics, And Proton Pump Inhibitors
22. Histamine modulators
23. Central Nervous System Stimulants
24. Anticoagulant drugs
25. Hemostatic Agents
26. Blood, Blood Products, and substitutes
27. Antipyretics: Acetaminophen, Arachidonic Acid Agents, Cox1 And Cox2 Inhibitors
28. Antiemetic Agents
29. Antiepileptics agents
30. Neuropharmacologic agents for neurologic conditions
31. Chemotherapeutic Agents
32. Antimicrobial Agents
33. Herbals medications and vitamin supplements
34. Minerals and electrolytes
35. Disinfection agents and antiseptics
36. Psychopharmacologic agents and psychiatric drug considerations
37. Cocaine, Methamphetamine, MDMA and Heroin
Part III. Clinical Subspecialties
38. Cardiac surgery
39. The Intensive Care Unit
40. Enteral and parenteral nutrition
41. Obstetrics
42. Pediatrics
43. Neurologic Surgery
44. Liver disease and liver transplantation
Part IV. Special Topics
45. Black Box FDA warnings and legal implications
46. Drug-Induced QT Prolongation
47. Drugs and Cancer Propagation
48. Lipid Lowering Agents
49. Serotonin Syndrome
Part V. New Vistas in Pharmacology
50. Novel Psychoactive Substances: synthetic cathinones and cannabinoid receptor agonists
51. New Vistas in Anesthetics, IV Induction Agents
52. New Vistas In Neuromuscular Blockers
53. Patient-Controlled Analgesia: The Importance of Effector Site Pharmacokinetics
54. Understanding anesthesia-induced memory loss
55. Novel Targets of Current Analgesic Drug Development.

Foreword; Preface; Contents; Contributors; Part I: Basic Pharmacologic Principles; Chapter 1: Pharmacokinetics and Pharmacodynamics of Anesthetics; Introduction; Absorption; Volume of Distribution; Clearance; Metabolism; Excretion; Elimination Rate Constant and Half-Life; Pharmacodynamics; Therapeutic Range and Therapeutic Monitoring; Drug Tables (Tables 1.5 and 1.6); References; Chapter 2: A Review of Mechanisms of Inhalational Anesthetic Agents; Introduction; Drug Class; Mechanism of Action; Indications; Clinical Pearls; Dosing Options; Drug Interactions; Clinical Pearl

Recovery from Inhalational Anesthetics Chemical Structures; References; Chapter 3: Pharmacokinetics, Pharmacodynamics, and Physical Properties of Inhalational Agents; Pharmacodynamics Properties of Inhalational Agents; Pharmacokinetics of Inhalational Agents; Delivery of Inhalational Agents; Fi (Inspired Gas Concentration); FA (Alveolar Gas Concentration); Uptake; Ventilation; Concentration Effect; Fa (Arterial Gas Concentration); Elimination of Inhalational Agents; Properties of Modern Inhalational Agents; Sevoflurane; Desflurane; Isoflurane; Nitrous Oxide; Halothane

Chemical StructuresReferences; Chapter 4: Principles of Total Intravenous Anesthesia; Basics of Total Intravenous Anesthesia (TIVA); Target-Controlled Infusion Technique; Manual Infusion Technique; Practical Conduct of Intravenous Anesthesia; Context-Sensitive Halftimes; Advantages of TCI over Manual Infusion Schemes for TIVA; Choice of Opioid; Cost of TCI-Based Anesthesia; Drawbacks of Inhalational Anesthesia; Advantages of TIVA; Future of TIVA; Chemical Structures; References; Chapter 5: Perioperative Considerations in Pharmacology; Introduction; Patient-Specific Factors

Weight Genetic, Phenotypic, and Cultural Differences; Cardiovascular Medications; Pulmonary Meds; Estrogen-Containing Medications; Antiplatelets; Psychotropic Medications; Antidepressants; Mood Stabilizers and Antipsychotics; Opioids; Herbal Medications; Smoking; Perioperative Physiology and Its Pharmacologic Impact; Conclusion; Chemical Structures; References; Part II: Drug Classes; Chapter 6: Anesthetic Induction Agents; Introduction; Nonbarbiturate Induction Agents; Propofol; Drug Class and Mechanism of Action; Indications; Dosing Options; Drug Interactions; Side Effects

Fospropofol Etomidate; Drug Class and Mechanism of Action; Indications; Dosing Options; Drug Interactions; Side Effects; Ketamine; Drug Class and Mechanism of Action; Dosing Options; Drug Interactions; Side Effects/Black Box Warnings; Summary; Chemical Structures; References; Chapter 7: Analgesics: Opiate Agonists, Mixed Agonists/Antagonists, and Antagonists for Acute Pain Management; Introduction; Opiate Agonists; Drug Class and Mechanism of Action; Indications/Clinical Pearls; Dosing Options; Drug Interactions; Side Effects/Black Box Warnings; Opioid Agonists/Antagonists