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000761094 24500 $$aStem cells, pre-neoplasia, and early cancer of the upper gastrointestinal tract /$$cMarnix Jansen, Nicholas A. Wright, editors.
000761094 260__ $$aCham :$$bSpringer,$$c2016.
000761094 300__ $$a1 online resource (488 pages).
000761094 336__ $$atext$$btxt$$2rdacontent
000761094 337__ $$acomputer$$bc$$2rdamedia
000761094 338__ $$aonline resource$$bcr$$2rdacarrier
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000761094 4901_ $$aAdvances in Experimental Medicine and Biology ;$$vv. 908
000761094 500__ $$aIncludes index.
000761094 5050_ $$aContributors; Chapter 1: Distal Esophageal Adenocarcinoma andßGastric Adenocarcinoma: Time forßaßShared Research Agenda; References; Part I: Introduction; Chapter 2: Clonal Evolution ofßStem Cells inßtheßGastrointestinal Tract; How Many Stem Cells Are inßtheßIntestinal Crypt?; What Factors Determine Stem Cell Number inßtheßCrypt?; Neutral Competition andßtheßRules ofßtheßGame; Dynamics inßtheßPyloric Glands ofßtheßStomach Epithelium; Clone Behavior inßCorpus Glands ofßStomach Epithelia; References; Chapter 3: The Complex, Clonal, andßControversial Nature ofßBarrett's Esophagus.
000761094 5058_ $$aIntroduction The Basic Unit ofßtheßHuman GI Tract Mucosa Is theßGland; Gland Phenotypes inßBarrett's esophagus; The Stem Cell Niche andßNiche succession inßBarrett's; Tracing Clonal Lineages inßBarrett's; Clonal Expansions inßNon-dysplastic Barrett's Esophagus; Clonal Dynamics andßExpansion inßBarrett's Esophagus; Combining Clonal Labeling withßPhenotype; Clonal Expansion Postradiofrequency Ablation (RFA); Conclusion; References; Chapter 4: A New Pathologic Assessment ofßGastroesophageal Reflux Disease: TheßSquamo-Oxyntic Gap; Introduction.
000761094 5058_ $$aProgression ofßGORD withßEmpiric PPI Therapy Definition ofßIrreversibility inßGORD: vCLO; Cause ofßGORD: Lower Esophageal Sphincter Damage; The Normal LOS andßConsequence ofßAbdominal LOS Damage; Mechanism ofßLOS Damage; Relationship Between LOS Damage andßGORD; Mechanism ofßMaintenance ofßLOS Pressure; In Search ofßAccurate Definitions; Histologic Definitions ofßEpithelia inßtheßEsophagus andßStomach; The Squamo-Oxyntic Gap; Definition ofßtheßSquamo-Oxyntic Gap; The Length ofßtheßSquamo-Oxyntic Gap; The Epithelial Composition ofßtheßSquamo-Oxyntic Gap.
000761094 5058_ $$aThe Location ofßtheßSquamo-Oxyntic Gap Autopsy Studies ofßtheßGOJ; The Squamo-Oxyntic Gap inßDifferent Populations; People Without GORD Symptoms; GORD Patients withßNo Endoscopic Abnormality; Patients withßaßvCLO at Endoscopy; The Distal Part ofßtheßSquamo-Oxyntic Gap Correlates withßDamage toßtheßAbdominal Los; Definition ofßtheßGastroesophageal Junction (GOJ); Genesis andßProgression ofßtheßSquamo-Oxyntic Gap; Columnar Metaplasia DueßtoßLOS Effacement Without Reflux; Columnar Metaplasia ofßtheßEsophageal Body DueßtoßLOS Failure andßReflux; A New Pathologic Test ofßLos Damage.
000761094 5058_ $$aMeasurement at Autopsy Measurement inßEsophago-Gastrectomy Specimens; Measurement at Endoscopy withßPresent Biopsy Forceps; Future Ideal Endoscopic Measurement; Conclusion; References; Part II: Cancer Progression in the Distal Esophagus; Chapter 5: Diagnosis by Endoscopy andßAdvanced Imaging ofßBarrett's Neoplasia; Introduction; Endoscopic Diagnosis ofßEarly Neoplasia inßBarrett's Esophagus; Use Best Endoscope Available; You Do Not Detect What YoußSee, YoußDetect What YoußRecognize; Perform aßSystematic Endoscopic Inspection; Advanced Imaging Techniques inßBarrett's Esophagus.
000761094 506__ $$aAccess limited to authorized users.
000761094 520__ $$aThis book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer. Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.
000761094 588__ $$aDescription based on print version record.
000761094 650_0 $$aGastrointestinal system$$xCancer$$xMolecular aspects.
000761094 7001_ $$aJansen, Marnix.
000761094 7001_ $$aWright, Nicholas A.
000761094 77608 $$iPrint version:$$aJansen, Marnix.$$tStem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract.$$dCham : Springer International Publishing, ©2016$$z9783319413860
000761094 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 908.
000761094 852__ $$bebk
000761094 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-41388-4$$zOnline Access$$91397441.1
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