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000761262 019__ $$a958481291$$a958780695
000761262 020__ $$a9783319421391$$q(electronic book)
000761262 020__ $$a3319421395$$q(electronic book)
000761262 020__ $$z9783319421377
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000761262 08204 $$a616.8/33$$223
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000761262 24500 $$aMitochondrial mechanisms of degeneration and repair in Parkinson's disease /$$cLori M. Buhlman, editor.
000761262 260__ $$aCham :$$bSpringer,$$c2016.
000761262 300__ $$a1 online resource (279 pages)
000761262 336__ $$atext$$btxt$$2rdacontent
000761262 337__ $$acomputer$$bc$$2rdamedia
000761262 338__ $$aonline resource$$bcr$$2rdacarrier
000761262 5050_ $$aPreface; Contents; Contributors; Chapter 1: Mitochondrial ROS andßApoptosis; 1.1 Reactive Oxygen Species andßMitochondrial Sources ofßTheir Generation; 1.2 Mitochondrial Redox Systems; 1.2.1 The Mitochondrial GSH andßGlutathione-Dependent Enzymes; 1.2.2 Mitochondrial Thioredoxin andßThioredoxin-Dependent Enzymes; 1.3 Overview ofßApoptosis Pathways; 1.3.1 Receptor-Mediated (Extrinsic) Apoptosis; 1.3.2 Mitochondria-Derived (Intrinsic) Apoptosis; 1.4 Mitochondrial ROS (mtROS) andßImplication forßIntrinsic Apoptosis.
000761262 5058_ $$a1.4.1 Cardiolipin Peroxidation andßInitiation ofßMitochondrial Apoptotic Signaling1.5 Role ofßMitochondrial GSH inßOxidant-Induced Intrinsic Apoptosis; 1.5.1 Mitochondrial GSH andßMitochondrial DNA Damage-ƯInduced Apoptosis; 1.6 Trx2 andßIntrinsic Apoptosis; 1.7 MtROS andßNeurodegenerative Disorders; 1.8 Summary andßPerspective; References; Chapter 2: Dopamine Metabolism andßReactive Oxygen Species Production; 2.1 Dopamine Metabolism; 2.1.1 Dopamine Biosynthesis; 2.1.2 Dopamine Degradation; 2.2 The Role ofßNeuromelanin inßDopaminergic Neurons; 2.3 ROS Production During Dopamine Metabolism.
000761262 5058_ $$a2.3.1 MAO-Linked ROS Production2.3.2 Autoxidation-Linked ROS Production; 2.3.3 Permeability Transition Pores (PTPs); 2.3.4 l-DOPA Toxicity; 2.4 Astrocyte-Neuron Interactions; 2.5 Genetic andßEnvironmental Factors Affecting DA Metabolism; 2.5.1 Genetic Factors; 2.5.1.1 TH Deficiency; 2.5.1.2 DAT Genetic Variants; 2.5.2 Environmental Factors; 2.6 Summary; References; Chapter 3: The Consequences ofßDamaged Mitochondrial DNA; 3.1 Introduction ofßMitochondrial DNA; 3.1.1 MtDNA Structure; 3.1.2 MtDNA Gene Composition; 3.2 Mutations inßmtDNA; 3.2.1 Oxidative-Induced mtDNA Mutation.
000761262 5058_ $$a3.2.2 Other Factors inßmtDNA Mutation3.3 MtDNA Maintenance andßRepair; 3.3.1 MtDNA Repair Mechanism-Base Excision Repair (BER); 3.3.2 Other Mechanisms Involved inßmtDNA Repair; 3.4 Damaged mtDNA Contributes toßMultiple Cellular Alterations; 3.4.1 Impaired Protein Synthesis andßFunction; 3.4.2 Decreased ATP Bioenergetics; 3.4.3 Nuclear Transcriptional Responses toßMitochondrial Defects; 3.5 MtDNA-Related (Mitochondrial) Diseases; 3.5.1 Common Mitochondrial Diseases; 3.5.2 Neurodegeneration andßmtDNA Mutations; 3.6 Potential Treatment Options; 3.7 Conclusion; References.
000761262 5058_ $$aChapter 4: The Role ofßChronic Inflammation inßtheßEtiology ofßParkinson's Disease4.1 Introduction; 4.1.1 Inflammation andßPD; 4.2 Parkinson Genes andßInflammation; 4.3 Inflammation andßToxin Animal Model ofßPD; 4.3.1 Toxin-Mediated Animal Model; 4.3.2 Inflammatory Mediated Animal Model; 4.4 Anti-inflammatory Treatment andßPD; 4.5 Conclusion; References; Chapter 5: Ion-Catalyzed Reactive Oxygen Species inßSporadic Models ofßParkinson's Disease; 5.1 Introduction; 5.1.1 Sporadic vs. Familial PD; 5.1.2 Etiology of PD; 5.1.3 Current Treatments; 5.2 Oxidative Stress andßAging Brain -- 5.3 Sources ofßROS inßDopaminergic Neurons.
000761262 506__ $$aAccess limited to authorized users.
000761262 588__ $$aDescription based on print version record.
000761262 650_0 $$aParkinson's disease$$xMolecular aspects.
000761262 7001_ $$aBuhlman, Lori M.
000761262 77608 $$iPrint version:$$aBuhlman, Lori M.$$tMitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease.$$dCham : Springer International Publishing, ©2016$$z9783319421377
000761262 852__ $$bebk
000761262 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-42139-1$$zOnline Access$$91397441.1
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000761262 980__ $$aEBOOK
000761262 980__ $$aBIB
000761262 982__ $$aEbook
000761262 983__ $$aOnline
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