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000761450 24500 $$aRecent trends in antifungal agents and antifungal therapy /$$cAmit Basak, Ranadhir Chakraborty, Santi M. Mandal, editors.
000761450 260__ $$a[India] :$$bSpringer,$$c©2016.
000761450 300__ $$a1 online resource
000761450 336__ $$atext$$btxt$$2rdacontent
000761450 337__ $$acomputer$$bc$$2rdamedia
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000761450 5050_ $$aPreface; Contents; About the Editors; 1: Fungi Fights Fungi: Tip-off in Antifungal Chemotherapy; 1.1 Introduction; 1.2 Fungi-Derived Antifungal Agents; 1.2.1 Griseofulvin; 1.2.2 Strobilurins; 1.3 Echinocandins, Pneumocandin and Papulacandin; 1.4 Fungi-Derived Antifungal Compounds Having Anticancer Activities; 1.4.1 Polyketides; 1.4.2 Terpenes; 1.5 Fungal Nitrogenous Compounds Including Non-ribosomal Peptides (NRPs); 1.6 Antifungal Metabolites from Coprophilous Fungi; 1.7 Mechanism of Antifungal Action; 1.8 Advancement of Biosynthesized Antifungal Agents.
000761450 5058_ $$a1.9 Echinocandin Past and Present: A Possible Clue1.10 Problem, Strategies and Prospects of Griseofulvin; 1.11 Strobilurins Synthesis: Success and Future Threat; 1.12 Pneumocandin B0 as the Starting Material of Synthetic Antifungal Caspofungin Acetate; 1.13 Future Perspectives; References; 2: Essential Oil and Antifungal Therapy; 2.1 Introduction; 2.2 What Is Essential Oil?; 2.3 Essential Oil Extraction and Composition; 2.4 Chemistry of Essential Oil; 2.4.1 Terpene and Terpenoid Molecules; 2.4.1.1 Monoterpenes; 2.4.1.2 Sesquiterpenes; 2.4.2 Functional Groups; 2.4.2.1 Acids; 2.4.2.2 Alcohols.
000761450 5058_ $$a2.4.2.3 Aldehydes2.4.2.4 Esters; 2.4.2.5 Ketones; 2.4.2.6 Oxides; 2.4.2.7 Lactones; 2.4.2.8 Ethers; 2.4.3 Phenolic and Phenylpropanoid Molecules; 2.4.4 Non-terpenoid Aliphatic Molecules; 2.4.5 Heterocyclic Molecules; 2.5 The Biosynthesis Pathway of Essential Oils; 2.5.1 Mevalonic Acid Pathway; 2.5.2 Shikimic Acid Pathway; 2.6 The Pharmacology of Essential Oils; 2.6.1 Absorption; 2.6.2 Distribution; 2.6.3 Metabolism; 2.6.4 Excretion; 2.7 Therapeutic Effects of Essential Oils and Their Constituents; 2.8 Antifungal Therapy with Essential Oils.
000761450 5058_ $$a2.9 Methods for Testing the Antifungal Activity of Essential Oil2.9.1 Broth or Agar Dilution Method; 2.9.2 Disk Diffusion Method; 2.9.3 Vapor Phase Test (VP); 2.9.4 Airtight Boxes; 2.9.5 Spore Germination Assay; 2.9.6 Poisoned Food Technique; 2.9.7 Percent Inhibition of Mycelia Growth; 2.9.8 Estimation of Minimal Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC); 2.10 Antifungal Effects of Essential Oils; 2.11 Importance of Natural Products; 2.12 Pathogenic Fungi; 2.13 Antifungal Mode of Action of Essential Oil.
000761450 5058_ $$a2.14 Interaction Effects Between Essential Oil Composition and Fungi2.15 Effective Factors on Antifungal Activity of Essential Oils; 2.16 Results on Antifungal Activity of Essential Oil Obtained from Previous Researches; References; 3: Antifungal Peptides with Potential Against Pathogenic Fungi; 3.1 Introduction; 3.2 Antimicrobial Peptides; 3.3 Insect Antifungal Peptides; 3.4 Amphibian Antifungal Peptides; 3.5 Mammalian Antifungal Cathelicidins; 3.6 Mammalian Antifungal Defensins; 3.7 Mammalian Antifungal Histatins; 3.8 Mammalian Lactoferrin-Derived Antifungal Peptides.
000761450 506__ $$aAccess limited to authorized users.
000761450 520__ $$aFungal infections have taken a new spectrum due to the increased incidence of multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat fungal infections is also narrow because of lesser probability of discovering drugs that would bypass affecting human cells and target fungal cells producing fewer side effects in patients. An approach has gained prominence in research is to look for bioactive antifungal compounds from natural to synthetic sources. It is necessary to discover new classes of antifungals to control the recent emergence of multi-drug resistant fungal infections. This book proposed a details top to bottom outline of antifungal compounds derived naturally or synthetically. The details of their modifications or synthetic analogues have been described, helpful to understand the structure-activity relationship which leads to new compound development in antifungal chemotherapy. Each chapter begins with a comprehensive, top-bottom in-depth discussion of antifungal agents with updated bibliographic references. This compendium will serve as a companion not only for Scientists, Researchers, and Professors, Medical Practitioners but also a valuable reference text for the university students.
000761450 650_0 $$aAntifungal agents.
000761450 7001_ $$aBasak, Amit.
000761450 7001_ $$aChakraborty, Ranadir.
000761450 7001_ $$aMandal, Santi M.
000761450 77608 $$iPrint version:$$tRecent trends in antifungal agents and antifungal therapy.$$d[India] : Springer, ©2016$$z8132227808$$z9788132227809$$w(OCoLC)939532088
000761450 852__ $$bebk
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