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Preface; Epigenetics, Energy Balance, andßCancer: Impact ofßEnvironmentally Induced Genetic Change WithoutßChanging theßGenome; Contents; Contributors; Chapter 1: Epigenetics andßCancer; Background; DNA Methylation; Characteristics ofßDNA Methylation; Regulation of DNA Methylation; Histone Modifications; Characterization ofßHistone Modifications; Regulation ofßHistone Modifications; Histone-DNA Interactions; Non-coding RNAs; Importance ofßEpigenetic Regulation ofßOrganism Development; Epigenetic Changes inßCancer; Aberrant DNA Methylation inßCancer.
Observed DNA Methylation Changes inßCancer Causes ofßAberrant DNA Methylation inßCancer; Aberrant Histone Modification inßCancer; Non-coding RNA Expression inßCancer; Altering theßCancer Epigenome: Epigenetic Therapies andßPrecision Medicine Applications; DNA Methyltransferase Inhibitors; HDAC Inhibitors; EZH2 Inhibitors; LSD1 Inhibitors; Bromodomain andßExtra-Terminal (BET) Protein Inhibitors; IDH Inhibitors; Opportunities forßPrecision Medicine; Conclusions andßFuture Research; References; Chapter 2: Epigenetics, Enhancers, andßCancer.
Enhancer Function andßSignature Epigenetic Features Approaches forßGlobal Enhancer Profiling; Super-Enhancers, Stretch Enhancers, andßEnhancer Clusters; Enhancer Readers, Writers, andßErasers; Nucleosome Depletion; H3K4me1; H3K27ac; Somatic Cancer Mutations toßChromatin-Related Proteins; Writers andßTFs; Readers/Chromatin-Looping Factors; Erasers; Enhancer Dysfunction inßCancer; Genetic Alterations toßEnhancers; Heritable Cancer Risk at Enhancers; Enhancers, Energy Balance, Obesity, andßAging; Somatic Cancer Mutations at Enhancers.
Enhancer Alterations AsßaßTherapeutic Target inßCancer Future Areas ofßStudy andßClinical Translation; References; Chapter 3: Early Life: Epigenetic Effects onßObesity, Diabetes, andßCancer; Epigenetics and Development; The Barker Hypothesis andßDevelopmental Origins ofßAdult Disease andßHealth; Epigenetics and Obesity; Epigenetics and Diabetes; Epigenetics and Cancer; Early Life Exposures andßEpigenetic Biomarkers; Challenges toßStudying Developmental Origins ofßAdult Disease; Conclusion; References; Chapter 4: Nutritional andßLifestyle Impact onßEpigenetics andßCancer.
Introduction Mechanisms Underlying Epigenetics; DNA Methylation; Histone Modifications; Noncoding RNAs; Factors Affecting theßEpigenome; Effect ofßEnvironmental Factors onßtheßEpigenome; Epigenetic Modifications by Nutritional Factors; Lifestyle Factors Affecting theßEpigenome; Social-Economic andßRacial Factors Affecting theßEpigenome; Summary andßConclusions; References; Chapter 5: Environmentally Induced Alterations inßtheßEpigenome Affecting Obesity andßCancer inßMinority Populations; Introduction; Environmentally Induced Epigenetic Alterations andßObesity.
Observed DNA Methylation Changes inßCancer Causes ofßAberrant DNA Methylation inßCancer; Aberrant Histone Modification inßCancer; Non-coding RNA Expression inßCancer; Altering theßCancer Epigenome: Epigenetic Therapies andßPrecision Medicine Applications; DNA Methyltransferase Inhibitors; HDAC Inhibitors; EZH2 Inhibitors; LSD1 Inhibitors; Bromodomain andßExtra-Terminal (BET) Protein Inhibitors; IDH Inhibitors; Opportunities forßPrecision Medicine; Conclusions andßFuture Research; References; Chapter 2: Epigenetics, Enhancers, andßCancer.
Enhancer Function andßSignature Epigenetic Features Approaches forßGlobal Enhancer Profiling; Super-Enhancers, Stretch Enhancers, andßEnhancer Clusters; Enhancer Readers, Writers, andßErasers; Nucleosome Depletion; H3K4me1; H3K27ac; Somatic Cancer Mutations toßChromatin-Related Proteins; Writers andßTFs; Readers/Chromatin-Looping Factors; Erasers; Enhancer Dysfunction inßCancer; Genetic Alterations toßEnhancers; Heritable Cancer Risk at Enhancers; Enhancers, Energy Balance, Obesity, andßAging; Somatic Cancer Mutations at Enhancers.
Enhancer Alterations AsßaßTherapeutic Target inßCancer Future Areas ofßStudy andßClinical Translation; References; Chapter 3: Early Life: Epigenetic Effects onßObesity, Diabetes, andßCancer; Epigenetics and Development; The Barker Hypothesis andßDevelopmental Origins ofßAdult Disease andßHealth; Epigenetics and Obesity; Epigenetics and Diabetes; Epigenetics and Cancer; Early Life Exposures andßEpigenetic Biomarkers; Challenges toßStudying Developmental Origins ofßAdult Disease; Conclusion; References; Chapter 4: Nutritional andßLifestyle Impact onßEpigenetics andßCancer.
Introduction Mechanisms Underlying Epigenetics; DNA Methylation; Histone Modifications; Noncoding RNAs; Factors Affecting theßEpigenome; Effect ofßEnvironmental Factors onßtheßEpigenome; Epigenetic Modifications by Nutritional Factors; Lifestyle Factors Affecting theßEpigenome; Social-Economic andßRacial Factors Affecting theßEpigenome; Summary andßConclusions; References; Chapter 5: Environmentally Induced Alterations inßtheßEpigenome Affecting Obesity andßCancer inßMinority Populations; Introduction; Environmentally Induced Epigenetic Alterations andßObesity.